Table 7 Results of meta-analysis of SCAN1 and replication cohorts

From: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

SNP CHR BP A0 A1 Study HG CONTROL OR 95% CI p-value Het p
A1 Freq A1 Freq
rs16982345 chr19 18500722 A G SCAN1 0.8 0.73 1.47 [1.33, 1.63] 6.81E−15
HG-IV 0.83 0.75 1.63 [1.35, 1.98] 2.80E−07
HG-TPN 0.82 0.74 1.61 [1.01, 2.60] 4.00E−02
META 1.5 [1.38, 1.65] 2.12E−19 6.62E−01
rs4865234 chr4 58355015 G A SCAN1 0.7 0.64 1.32 [1.20, 1.43] 7.95E−10
HG-IV 0.72 0.66 1.43 [1.16, 1.79] 9.00E−04
HG-TPN 0.75 0.63 1.82 [1.20, 2.70] 2.81E−03
META 1.33 [1.23, 1.62] 9.29E−12 7.27E−01