Table 6 Replication results based on Fisher’s exact test for the two most significantly associated loci in SCAN1 and SCAN2: rs16982345 (chr19p13.11), rs4865234 (chr4q12), and the three association signals in SCAN1 with p > 5 × 10−8 and p < 1 × 10−6, rs5754397 (SYN3) rs78353059 (MMADHC/RND3), and rs56108151 (TMEM38B/ZNF462)

From: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

  N Genotype 1 Genotype 2 Genotype 3 p-value OR 95% CI
rs16982345   GG AG AA    
HG-IV 789 540 229 20    
CONTROL 581 330 210 41 2.80 × 10−7 1.63 1.35–1.98
HG-TPN 103 68 33 2    
NO NVP 136 75 51 10 0.04 1.61 1.01–2.60
rs4865234   AA AG GG    
HG-IV 778 404 312 62    
CONTROL 603 259 273 71 3.50 × 10−4 1.35 1.14–1.59
HG-TPN 110 64 38 8    
NO NVP 143 57 66 20 2.81 × 10−3 1.81 1.21–2.73
rs5754397   CC CT TT    
HG-IV 774 218 353 203    
CONTROL 606 180 273 153 0.51 0.95 0.82–1.11
HG-TPN 106 37 44 25    
NO NVP 141 44 64 33 0.72 1.07 0.74–1.56
rs78353059   AA AG GG    
HG-IV 779 735 42 2    
CONTROL 596 561 34 1 0.82 1.07 0.66–1.71
HG-TPN 105 99 6 0    
NO NVP 136 125 11 0 0.62 1.43 0.48–4.80
rs56108151   AA AG GG    
HG-IV 780 625 150 5    
CONTROL 594 495 97 2 0.06 0.78 0.59–1.02
HG-TPN 108 86 22 0    
NO NVP 141 117 23 1 0.64 0.86 0.45–1.65