Table 4 Results of GWAS of NVP as an ordinal response (SCAN2) with p < 5 × 10−8. The directions of effect correspond to the minor allele, listed second

From: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Cytoband Marker Position Alleles MAF p-value β 95% CI SCAN1 p-value SCAN1 OR SCAN1 95% CI Gene context
19p13.11 rs16982345 19:18500722 G/A 0.25 2.4 × 10−41 −0.104 [−0.120, −0.089] 6.81 × 10−15 0.68 [0.615, 0.751] GDF15[]-LRRC25
4q12 rs143409503 4:58351064 −/AGC 0.34 9.2 × 10−24 −0.072 [−0.086,−0.058] 1.86 × 10−10 0.752 [0.688, 0.822] IGFBP7—[]
11q22.1 rs2508362 11:101260798 A/G 0.199 1.7 × 10−12 0.06 [0.043,0.076] 1.06 × 10−04 0.819 [0.741, 0.904] PGR—[]–TRPC6
6q15 rs4707680 6:92294371 T/C 0.427 2.8 × 10−10 0.043 [0.030, 0.056] 5.79 × 10−02 0.924 [0.851, 1.00] MAP3K7-[]
22q11.23 rs201838815 22:24753023 T/− 0.02 5.8 × 10−9 −0.159 [−0.212, −0.105] 2.88 × 10−02 0.685 [0.480, 0.979] [SPECC1L,SPECCl-ADORA2A]
6p12.1 rs7761177 6:55151343 T/C 0.495 6.2 × 10−9 −0.039 [−0.052, −0.026] 1.70 × 10−06 0.82 [0.755, 0.889] HCRTR2-[]–GFRAL
4q31.21 rs4690766 4:144030040 G/C 0.358 1.3 × 10−8 −0.04 [−0.054, −0.026] 1.02 × 10−01 0.932 [0.856, 1.01] INPP4B—[]–USP38