Table 2 Results of the genome-wide association study of no NVP vs HG (SCAN1) with p < 10−6. The directions of odds ratios (OR) correspond to the minor allele, listed second

From: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Cytoband Marker Position Alleles MAF SCAN1 p-value SCAN1 OR SCAN1 95% CI SCAN2 p-value SCAN2 effect size SCAN2 95% CI Gene context
19p13.11 rs45543339 19:18503194 C/T 0.25 1.9 × 10−14 0.668 [0.601,0.743] 5.7 × 10−39 −0.104 [−0.120, −0.890] [LRRC25]
4q12 rs143409503 4:58351064 −/AGC 0.34 4.5 × 10−10 0.752 [0.687,0.824] 6.8 × 10−25 −0.073 [−0.087, −0.0587] IGFBP7—[]
22q12.3 rs5998706 22:33440890 C/T 0.49 1.6 × 10−7 0.786 [0.717,0.860] 3.5 × 10−5 −0.03 [−0.044, −0.016] [SYN3]
2q23.3 rs114571265 2:150910809 G/C 0.024 8.3 × 10−7 0.388 [0.253,0.595] 3.6 × 10−4 −0.087 [−0.133, −0.039] MMADHC—[]—RND3
9q31.2 rs56108151 9:109514426 A/G 0.095 9.2 × 10−7 0.677 [0.575,0.797] 5.9 × 10−4 −0.034 [−0.062, −0.017] TMEM38B—[]—ZNF462