Fig. 2 | Nature Communications

Fig. 2

From: Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin

Fig. 2

AK and cSCC methylomes show cancer-specific features. a Methylation status of the different epigenomic substructures in the epidermis of AK (left) and cSCC (right) patients compared to healthy controls. The box plots indicate highly significant (P ≤ 9.1E−77, two-sided t-test) hypermethylation of the CpG islands and hypomethylation of the Open Sea probes in both AK and cSCC samples. b Fractions of hyper and hypomethylated CpGs in AK and cSCC epidermis, within different epigenomic substructures and in comparison to healthy skin. c Probes within lamina-associated domains (LADs) are significantly (P ≤ 3.4E−288, two-sided t-test) hypomethylated in AK and cSCC when compared to healthy epidermis

Back to article page