Table 2 Highly polymorphic genes and genomic regions of M. leprae

From: Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

Gene or region Description Non-synonymous mutations (multi-allele loci) Synonymous mutations Homoplasy
ML0411 Serine-rich antigen 32 (4) 1 4
ML1040c Putative ATP-dependent helicase 19 (1) 0 0
fadD9 Probable fatty-acid-CoA ligase 16 1 1
ML1750c Putative nucleotide cyclase 17 1 0
ML1512c Putative ribonuclease J 17 0 0
ribD Bifunctional enzyme riboflavin biosynthesis protein 17 0 1
rpoB DNA-directed RNA polymerase (beta chain) 13 (1) 1 3
ML1753c Probable transcriptional regulatory protein 9 0 0
gyrA DNA gyrase (subunit A) 8 8 1
ML1300 Conserved hypothetical protein 8 0 0
nth Endonuclease III 7 0 1
ctpC Metal cation-transporting P-type ATPase C 7 2 0
rpoC DNA-directed RNA polymerase (beta chain) 7 5 0
ML2687c Probable conserved transmembrane protein 7 0 0
ML1052c Conserved hypothetical protein 7 1 0
ML0009 Hypothetical protein 6 1 0
ML0283 Cation-efflux transporter component 6 1 0
ML2700 Conserved transmembrane protein 6 7 0
mfd Transcription-repair coupling factor 6 1 0
ppsC Phenolphthiocerol and DIM synthesis 6 1 0
ethA Activates the pro-drug ethionamide 5 0 0
trpE Biosynthesis of tryptophan (at the first step) 5 1 0
pknB Transmembrane serine/threonine-protein kinase 5 3 0
fas Fatty acid synthase 5 1 0
esxA Early secretory antigenic target 2 0 1
lsr2 Dominant T-cell antigen and stimulates lymphoproliferation. 4 1 3
folP1 Dihydropteroate synthase 5 (2) 1 2
ML1752c Conserved hypothetical protein 2 1 1
ppsA Phenolphthiocerol and DIM synthesis 4 3 1
ML0803 Two-component sensor kinase 2 (1) 0 0
ML0237 Conserved hypothetical protein (pseudogene) NA 1 1
ML0010c-ppiA Intergenic region NA 3 1