Table 1 Mutations in genes associated with drug resistance

From: Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

Sample folP1 ML0224 rpoB ML1891c gyrA ML0006 gyrB ML0005 fadD9 ML0484c ribD ML1340 ethA ML0065 pks4 ML1229 nth ML2301c
2188—2007 . . . . . G62D1 . . .
2188—2014 . . . . . G62D . . .
85054 P55L S456L        
G52E . . W878* D256N . . R197*
2DDS P55R . . . L396P S58R . . .
LRC-1A . . I851T V214G . . . . .
Airaku-3 T53I .   . N304fs . . . .
Amami P55L . . . . R236C . . L145fs
ARLP_08 . H200Y . . . . . . .
ARLP_10 . . . . Y927D G61C . . .
ARLP_30 . . G1115R . . . . . .
ARLP_52 . . G1115R . . . . . .
Bn8-46 P55R . . . . . . . .
Bn8-52 P55LN145H . . . W1108fs . . .  
Br14-1 P55R S456M . . G148fs . . . .
Br14-2 P55R S456M . . G148fs . . . .
Br14-3 P55L H451Y A91V . Q107* G94D . . E173*
G448D
T433I
Br14-4 P55R S456L . . L396P I56T .   
Y171N
Br14-5 P55R S456L . . A919E C222W . . .
Br2016-15 P55L . V731I T503I G796S A63T . M14I N142fs
Br2016-16 . . . . L998fs K267fs . . .
Br2016-18 . . S307L . . . . . .
Br2016-21 . . . . . . . I932fs .
Kusatsu-6 P55L T433I . . . . K477fs   
D441Y
Ml10-93 P55R . . . R73fs S58R . . .
Ml10-98 . . . . . A10fs . . .
Ml2-10 T53R . . . . . . . .
Ml6-50 T53R . . . . . . . .
Ml6-55 T53R . . . . . . . .
Ng14-35 P55R . S307L . A594T D34del . . .
S15 T53I G432S . . D466N Q117* D63N T334I G146fs
H451D D323N
S9 T53I R791Q . . . S58N . . .
Thai-237 . . I851T . . . . . .
US57 . . G362E . . . . . .
Zensho-2 P55L . . . Y562fs G94D . . .
Zensho-4 T53I P51S A91V D464N R314C D77N A25T Q1719* L163fs
S456L
Zensho-5 P55L S456L . . . G204C G390A . N142fs
P583L
Zensho-9 P55L H451Y . . A973T P150L P383L . E122*
G681S
  1. In bold, substitutions or residues known to confer drug resistance in M. leprae; * premature stop codon, fs frameshift, dot (.) wild type. RpoB numbering is based on M. leprae, E. coli numbering in brackets: 51 (126), 52 (127), 171 (246), 200 (275), 432 (507), 433 (508), 441 (516), 448 (523), 451 (526), 456 (531), 681 (756), 791 (866). 1Coverage below the threshold, both “2188” isolates come from the same patient but after an interval of 7 years28