Fig. 4 | Nature Communications

Fig. 4

From: Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae

Fig. 4

Mutations of M. leprae genes associated with antimicrobial resistance. Triangles point to the location of the mutation in the protein. Black triangles indicate known resistance-conferring mutations identified in this study that are situated in the drug resistance determining regions (DRDR): D dapsone, Q quinolone, R rifampicin. Orange border means the mutation was found to be homoplasic. Triangle size reflects the number of isolates from this study harboring the mutation, ranging from 1 to 17. Frameshifts and premature stop codons are in turquoise. Substitutions predicted to have an impact on the biological function of the protein75 are in bold. Proteins are drawn to scale

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