Table 2 Loss of IL-6 leads to reduced metastatic spread of tumours in ∆122p53 mice

From: 133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

Comparison Genotype Local Extensive χ2-statistic p-value
Group 1 ∆/∆ IL-6+/+ 2 17 1.77 0.18
Group 2 ∆/∆ IL-6+/− 2 4
Group 1 ∆/∆ IL-6+/+ 2 17 6.6 0.01*
Group 2 ∆/∆ IL-6−/− 5 4
Group 1 ∆/+ IL-6+/+ 1 5 0.321 0.57
Group 2 ∆/+ IL-6+/− 1 2
Group 1 ∆/+ IL-6+/+ 1 5 0.19 0.66
Group 2 ∆/+ IL-6−/− 0 1
Comparison Genotype No metastasis Metastasis χ2-statistic p-value
Group 1 ∆/∆ IL-6+/+ 3 3 0.225 0.64
Group 2 ∆/∆ IL-6+/− 2 1
Group 1 ∆/∆ IL-6+/+ 3 3 2.857 0.09
Group 2 ∆/∆ IL-6−/− 4 0
Group 1 ∆/+ IL-6+/+ 8 5 4.53 0.03*
Group 2 ∆/+ IL-6+/− 15 1
Group 1 ∆/+ IL-6+/+ 8 5 0.642 0.42
Group 2 ∆/+ IL-6−/− 3 4
  1. Summary of χ2-statistic and p-value for local vs. extensive organ involvement by T lymphomas between the genotypes and number of metastasis of sarcomas between the genotypes
  2. *p < 0.05 was considered to be significant