Fig. 8 | Nature Communications

Fig. 8

From: 133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

Fig. 8

Model of how the ∆133p53 isoform regulates the JAK-STAT3 and RhoA-ROCK pathways to promote inflammation and invasion. Wt p53 is activated by some (as yet undefined) stress signal, which turns on ∆133p53. ∆133p53 increases IL-6, which, then binds to its receptor and signals through the JAK-STAT pathway to amplify the IL-6 signal further. The JAK-STAT pathway, now constitutively activated by ∆133p53, drives actin polarisation, cell migration via RhoA-ROCK signalling and alters migration of immune cells

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