Table 1 Characteristics of DILI patients

From: The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

  All patients Hepatocellular injury Cholestatic injury Mixed injury
n 21 9 7 5
Age (years) 49.3 ± 19.6 49.7 ± 19 47.7 ± 18.1 51.8 ± 26.8
Gender (F/M) 10/11 5/4 3/4 2/3
ALT (U/L) 438.8 ± 428.7 163.1 ± 109.5 722.4 ± 528.8 314.0 ± 89.8
AST (U/L) 324.9 ± 393.7 123.7 ± 58.8 568.2 ± 514.9 168.4 ± 70.2
GGT (U/L) 386.5 ± 433.1 744.5 ± 646.2 38.9 ± 35.6 296.2 ± 268.4
ALP (U/L) 360.8 ± 419.2 655.6 ± 617.1 143.2 ± 72.2 339.8 ± 194.3
TBIL 7.5 ± 6.0 6.6 ± 5.4 8.4 ± 7.4 7.3 ± 4.8
Severity, n (%)
 Mild 6 (28.6) 3 (33.3) 2 (28.6) 1 (20)
 Moderate 11 (52.4) 3 (33.3) 5 (71.4) 3 (60)
 Severe 3 (14.3) 2 (22.2) 0 (0) 1 (20)
 Fatal 1 (4.8) 1 (11.1) 0 (0) 0 (0)
  1. ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma glutamyl transferase, TBIL total bilirubin
  2. Data are expressed as mean ± SD