Fig. 6 | Nature Communications

Fig. 6

From: The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

Fig. 6

MCJ expression is increased in human DILI. ac Human samples from healthy control subjects (Healthy) (n = 7) and from patients with drug-induced liver injury (DILI) (n = 21). a MCJ expression in liver was determined by immunohistochemistry and b quantified. c Correlation between MCJ expression and drug grade of mitochondrial liability in DILI patients. d, e Human samples from healthy control subjects (Healthy) (n = 7) and from patients with acetaminophen-induced liver injury (APAP) (n = 24). a MCJ expression in liver was determined by immunohistochemistry and b quantified. Scale bar corresponds to 100 μm. Values are represented as mean ± SEM. *P < 0.05 (Student’s t test) (DILI vs. Healthy, mitochondrial hazardous vs. non-mitochondrial hazardous, and APAP vs. Healthy)

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