Table 3 Grignard scope

From: Highly enantioselective catalytic synthesis of chiral pyridines

Entry R′MgX R Product Yield (%)a ee (%)b
1 EtMgBr Ph 2a 94 93
2 PrMgCl Ph 5a 75 93
3 HexMgBr Ph 5b 81 95
4 i-PentMgBr Ph 5c 65 97
5 i-BuMgBr Hexyl 5d 56 64
6c c-PentMgBr Hexyl 5e 54 89
7 CH2=CH(CH2)2MgBr Hexyl 5f 91 93
8 CH2=CH(CH2)3MgBr Ph 5g 66 90
9 Ph(CH2)2MgBr Hexyl 5 h 89 97
10d MeMgBr Hexyl 5i 50 93
11e PhMgBr Hexyl 5j 84 0