Fig. 1 | Nature Communications

Fig. 1

From: Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice

Fig. 1

Mice ancestrally exposed to TBT develop a leptin resistant “thrifty phenotype”. Body weight a and relative body composition b of F4 DMSO (n = 10) and TBT (n = 12) males throughout the course of the experiment. c Percentage of body weight (BW), lean weight (LW), and fat weight (FW) loss after 16 h of fasting for DMSO (n = 10) and TBT (n = 12). d Plasma levels of leptin in animals at 33 weeks of age (after the diet challenge). D, DMSO; T, TBT. Statistical significance was determined using two-way ANOVA in panels a, b and one-way ANOVA in panel c and d. Pair-wise Bonferroni post-tests were used to compare different groups in all panels. Data is presented as mean ± s.e.m. *p < 0.05; **p < 0.01; ***p < 0.001

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