Fig. 2 | Nature Communications

Fig. 2

From: Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

Fig. 2

Mode of 5C4 binding to antigenic site Ø is similar to that of D25. a 5C4–RSV F complex crystal structure in ribbon and molecular surface representation. Two pre-F protomers are shown as dark and light gray surfaces, and the third protomer is shown as ribbons with F1 colored green and F2 colored blue. The 5C4 Fab bound to the F protomer is also displayed in ribbon representation, with the heavy chain colored pink and the light chain colored white. The other 5C4 Fabs are colored similarly but shown in surface representation. b RSV F protomers are shown in ribbon representation and colored as above. Fabs (upper) and antibody variable domains (lower) are shown as a molecular surface with light chains colored white and the heavy chains of 5C4 and D25 colored pink and red, respectively. The difference in vertical (upper) and horizontal (lower) angle of approach between 5C4 and D25 is represented as intersecting lines with a measured angle of ~ 60° and ~ 45°, respectively

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