Fig. 2 | Nature Communications

Fig. 2

From: Cisplatin is retained in the cochlea indefinitely following chemotherapy

Fig. 2

Cisplatin is readily cleared from most organs but is retained in the cochlea. a ICP-MS measured platinum concentrations in whole mouse organs isolated throughout the first 24 h following a single i.p. injection of cisplatin. 0-h data points represent mice prior to injection of cisplatin. Concentrations are normalized to organ mass (ng Pt per g of organ, left y-axis) or expressed as parts per billion (ppb, right y-axis) for whole blood. Platinum levels peak in most organs 1 h after injection. Concentrations vary significantly across organs and are highest in kidney and liver. n = 3–4 mice per time point. b Concentrations of cisplatin in whole mouse organs throughout the complete 42-day cisplatin regimen. The three, 4-day long cycles of once-daily i.p. cisplatin are indicated by blue shading. In most organs, platinum levels increase following injection and then decline during the recovery period. In contrast, platinum progressively accumulates in cochlea with no apparent elimination. n = 3–4 mice at each time point for all organs. c Concentrations of platinum in whole mouse organs at the end of the cisplatin regimen and following a subsequent 60-day recovery. During this recovery period, platinum was significantly eliminated from all organs except the cochlea and femur. n = 3–4 mice in each group. Multiple two-tailed t-tests with correction for multiple comparisons by the Holm–Šidák method were used to determine significance. Data are expressed as mean ± s.e.m. ns not significant, *P < 0.05

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