Fig. 5 | Nature Communications

Fig. 5

From: Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

Fig. 5

Crystal structure of PGT128 with an oligomannose mimetic. a Overview of the crystal structure of PGT128 bound to NIT68A. The Fab heavy and light chains are shown in orange and gray, respectively. The NIT68A glycoside is shown in ball-and-stick representation, with carbons in cyan and oxygens in red. b View of the NIT68A-binding site of PGT128, with 2Fo-Fc electron density (at σ = 1) for the mimetic shown as a mesh. c View of the NIT68A-binding site of PGT128, colored as above, with the structure of PGT128 in complex with Man9 (PDB 3TV3) superimposed and shown in lavender ribbon and ball-and-stick representation for the respective Fab and ligand. d Stereo view of the PGT128 Fab CDRH3, showing the 2Fo-Fc electron density contoured at σ = 1 for residues 94–101 (shown as sticks)

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