Figure 3: Nature Communications

Fig. 3

From: Functional mapping and annotation of genetic associations with FUMA

Fig. 3

Regional plot of the locus 16q.12.2 of BMI GWAS. a Extended region of the FTO locus, which includes prioritized genes RBL2 and IRX3. Genes prioritized by FUMA are highlighted in red. b Zoomed in regional plot of FTO locus with, from the top, GWAS P-value (SNPs are colored based on r 2), CADD score, RequlomeDB score and eQTL P-value. Non-GWAS-tagged SNPs are shown at the top of the plot as rectangles since they do not have a P-value from the GWAS, but they are in LD with the lead SNP. eQTLs are plotted per gene and colored based on tissue types. In the plots of CADD score, RegulomeDB score and eQTLs, SNPs which are not mapped to any gene are colored gray