Figure 1: Nature Communications

Fig. 1

From: Functional mapping and annotation of genetic associations with FUMA

Fig. 1

Overview of FUMA. FUMA includes two core processes, SNP2GENE and GENE2FUNC. The input is GWAS summary statistics. SNP2GENE prioritizes functional SNPs and genes, outputs tables (blue boxes), and creates Manhattan, quantile–quantile (QQ) and interactive regional plots (box at right bottom). GENE2FUNC provides four outputs; a gene expression heatmap, enrichment of differentially expressed gene (DEG) sets in a certain tissue compared to all other tissue types, overrepresentation of gene sets, and links to external biological information of input genes. All results are downloadable as text files or high-resolution images