Fig. 2 | Nature Communications

Fig. 2

From: Stress-induced plasticity of dynamic collagen networks

Fig. 2

Simulation of collagen bundle formation by contracting cell pairs. a The network configuration in an elastic model (without any sliding or merging events). b The network configuration predicted by our plastic model. c The relative increase of fiber density ΔF/F of collagen bundles compared with the background at varying cell−cell distance. Here the cell−cell distance α is normalized by the cell size α. Red: plastic deformation with sliding events. Blue: pure elastic response of the network. At any given distance, the results from elastic (T = 0 min) and plastic (T = 15 min) are statistically distinct (t-test, p = 0.0007, N = 8). d The irreversibility of a collagen bundle depends on both cell contractility (β) and maturation time T d . Here the irreversibility is characterized by ΔF/F after the cell traction force is released. The cell−cell distance is fixed at d = 7a. Error bars in c, d: mean ± SD, obtained from eight different realizations

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