Fig. 10 | Nature Communications

Fig. 10

From: Survival of pancreatic cancer cells lacking KRAS function

Fig. 10

KRAS knockout signature overlaps with subtype-specific signatures of PDAC. a Univariate and multivariable Cox proportional hazards models on overall survival in the entire TCGA PDAC cohort, including clinical covariates and gene expression signatures, revealed that the combined KRAS knockout signature was independently associated with worse survival. Hazard ratios (HR) and p values (Cox regression) are reported. A comparison between a model with and without an interaction term (likelihood ratio test) was used to determine independence (p > 0.05) between significant covariates in multivariable analysis and the combined KRAS knockout signature. b Kaplan–Meier plots of survival in human PDAC patients from the TCGA cohort based on tumors most correlated (top quintile) and least correlated (bottom quintile) with the quasi-mesenchymal (QM) subtype from Collisson et al.21, basal subtype signature from Moffitt et al.46, and the squamous subtype signature from Bailey et al.45 (n = 33 most correlated and n = 33 least correlated tumors). Log-rank (Mantel–Cox) p values are shown. c Tables show percentage of tumor/patient overlap of top (most correlated) and bottom (least correlated) quintiles of tumors (out of n = 33 per group) in each signature. Green shading corresponds to degree of overlap (white = 0%, dark green = 100%). p values for significance of overlap (between n = 33 groups) within the TCGA PDAC cohort (out of 166 total tumors) are also shown (hypergeometric test). Red shading corresponds to significance of overlap (white = 0.05, dark red = minimum p value)

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