Fig. 4 | Nature Communications

Fig. 4

From: Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

Fig. 4

Correlation between CXCL9 induction and T-cell infiltration or galectin-3 expression in human tumor biopsies treated ex vivo with galectin antagonists. Samples corresponding to those of Table 1. Correlation probabilities and non-parametric correlation coefficients are shown in each graph. a Correlation between CXCL9 induction (fold change induction in samples treated with IFNγ and LacNAc versus their corresponding samples treated with IFNγ alone) and galectin-3 expression in responding or non-responding tumors (having defined responding tumors such as those were CXCL9 fold change was at least two). b Correlation between CXCL9 and CD3 expressions in tumors treated with LacNAc alone and stratified depending on their T-cell infiltration. Tumors were considered as highly infiltrated if their CD3 expression was bigger than the average CD3 expression of all the tumor samples

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