Fig. 2 | Nature Communications

Fig. 2

From: Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

Fig. 2

Overall survival (OS) in TCGA ovarian cancer patients who received platinum-based therapy. a Bi-allelic alterations in HR-related genes are associated with significantly longer overall survival (OS, p = 0.005; log-rank test). b Forest plot showing results from a multivariate Cox proportional-hazards model adjusting for stage (continuous: I, II, III, IV) and age (continuous) demonstrates that bi-allelic pathogenic alterations are associated with significantly longer overall survival (hazard ratio (HR) = 0.46, 95% confidence interval (CI) = 0.28–0.75, p = 0.002, Genotype is a categorical variable, bi-allelic vs. other). Stage (HR = 1.67, 95% CI = 1.25–2.21, p < 0.001) and age (HR = 1.01, 95% CI 1.00–1.03, p = 0.02) are also associated with outcome on multivariate analysis

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