Fig. 3 | Nature Communications

Fig. 3

From: Continual reproduction of self-assembling oligotriazole peptide nanomaterials

Fig. 3

Autocatalytic formation of oligotriazole peptide nanospheres. a HPLC traces (210 nm) monitoring the autocatalytic formation of tris(triazole) Boc-L-HAla-OH (5) by cycloaddition reaction of tripropargylamine with the azidoderivative Boc-L-HAla(N3)-OH.DCHA (1) in the presence of 0.016 equiv. of tris(triazole) 5. The retention times for all the species were verified by mass spectrometry and the use of known standards. b Autocatalytic formation of tris(triazole) peptide 5 in the presence of 0, 0.016, or 0.1 equivalents of tris(triazole) peptide 5. Sigmoidal growth curves are observed and can be fit to a four-parameter logistic equation (solid lines), which are typically used to describe autocatalytic processes. HPLC spectra (210 nm) were used to monitor the progress of the CuAAC reaction. Retention times were verified by mass spectrometry

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