Fig. 10 | Nature Communications

Fig. 10

From: RSV glycoprotein and genomic RNA dynamics reveal filament assembly prior to the plasma membrane

Fig. 10

Model of RSV filament formation prior to the plasma membrane via the rapid distension of vesicles along microtubules. Progeny RSV G is initially translated into the endoplasmic reticulum before being glycosylated and transported through the golgi network to the plasma membrane. RSV G, labeled with SBA, then is endocytosed and enters the recycling endosome compartment via clathrin-coated vesicles. These vesicles, which also contain RSV F, are distended by dynein along microtubules into filamentous particles prior to being loaded with RSV genomic RNA. During this recycling process, the vesicles colocalize with caveolin. The filaments then mature by merging with the plasma membrane through an unknown process