Fig. 7 | Nature Communications

Fig. 7

From: RNA localization is a key determinant of neurite-enriched proteome

Fig. 7

RNA localization as the key determinant of protein localization and potential functional roles for RBPs. Scheme illustrating the contribution of mRNA localization to neurite-localized proteome. Neurite-localized proteins (proteomics log2 neurites/soma > 1, P-values < 0.05) were split into three groups based on encoding mRNA localization pattern (upper panel): proteins encoded by localized mRNAs (RNA-seq log2 neurites/soma > 1, P-values < 0.05), proteins encoded by moderately enriched mRNA (0 < RNA-seq log2 neurites/soma < 1), and proteins localized to neurites without a significant contribution of mRNA localization (RNA-seq log2 neurites/soma < 0). Boxplot (middle panel) shows mean Ribo-seq log2 neurites/soma values for these three gene categories. Neuron schematic representation (lower panel) illustrates the predominant mechanism of protein localization through local translation of neurite-localized mRNAs

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