Fig. 6 | Nature Communications

Fig. 6

From: A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

Fig. 6

Inhibitory effects of telmisartan, alendronate and chlorpropamide on COX activity measured by COX inhibition assays. ac The inhibition rates of telmisartan, alendronate and chlorpropamide measured by the COX fluorescent activity assays on the mouse kidney lysates. d, e The relative COX activity inhibition rates of telmisartan, chlorpropamide and alendronate on COX-1 and COX-2, measured by the COX fluorescent activity assays on the tissue extracts from both kidney d and macrophage e lysates. f The results on the competitive binding of [3H] celecoxib for different COX-2 inhibitors measured by the radioligand-based binding assays. Control: the radioactivity of the sample with [3H] celecoxib only. *: P < 0.05, **: P < 0.01, ***: P < 0.001, Newman–Keuls multiple comparison test. Here, data show the mean with the standard deviation of three independent experiments, each of which was performed with triplicates

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