Table 2: Kinetic parameters for the inhibition of factor Xa variants

From: Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors

  Antithrombin Antithrombin TFPIα rTAP Apixaban Edoxaban
  k 2, uncatalyzed (M−1 s−1 × 103) k 2, UFH (M−1 s−1 × 106) K i (nM) K i (nM) IC50 (nM) IC50 (nM)
pd-FXa  1.55 ± 0.13 3.59 ± 0.39 ND  0.87 ± 0.18  2 ± 0.2  3 ± 2
wt-FXa 4.07 ± 0.20 3.09 ± 0.64  1.62 ± 0.25  0.70 ± 0.04   1 ± 0.2  2 ± 1
FXa-A  0.12 ± 0.02  1.55 ± 0.46 4.35 ± 1.32 26.30 ± 8.45  93 ± 23  23 ± 14
FXa-B  0.41 ± 0.03  1.02 ± 0.40  4.41 ± 1.89  7.92 ± 1.88 652 ± 200 218 ± 31
FXa-C 0.95 ± 0.11 6.73 ± 3.61 6.46 ± 1.63 20.24 ± 6.56  716 ± 247 375 ± 215