Fig. 1 | Nature Communications

Fig. 1

From: Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

Fig. 1

The boundaries of GRBs are highly consistent regardless of the thresholds or species involved. a The human MEIS1 locus is spanned by arrays of conserved noncoding elements (CNEs) identified in comparisons with opossum, chicken and spotted gar. These CNEs can be visualised as a smoothed density, shown here as a horizon plot. The boundaries of the proposed GRBs at the MEIS1 locus are highly consistent regardless of the species or thresholds involved. b All hg19-galGal4 GRBs centred and ordered by length of the GRB. c Distribution of CNEs in a window of 8 Mb around the centre of the hg19-galGal4 GRBs for different sets of CNEs. d Overlap of putative GRBs obtained using comparisons between hg19-monDom5 and hg19-lepOcu1 with these sets of GRBs identified using CNEs using hg19-galGal4 (70%/50 bp)

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