Fig. 3 | Nature Communications

Fig. 3

From: Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Fig. 3

Biosynthetic gene cluster and proposed biosynthetic pathway of ilamycins. a Organization of the ilamycin gene cluster. b Biosynthetic pathway of ilamycins. c The prenylation of Trp. d The nitration of Tyr. e The biosynthesis of L-AHA unit. f The post-tailoring biosynthetic steps en route to ilamycins. A adenylation, C condensation, T thiolation, MT methylation, TE thioesterase, KS keto synthases, ACP acyl carrier protein, AT acyl transferase, AT-L acyl transferase-like protein, DH dehydratase, KR keto reductase, ER enoyl reductase