Fig. 4 | Nature Communications

Fig. 4

From: Plasmonic silver nanoshells for drug and metabolite detection

Fig. 4

Pharmacokinetic study based on mannitol detection in bio-fluids. Mass spectra of 0.5 μL of native serum showing a sodium-adducted and b silver-adducted characteristic molecular peaks of glucose and mannitol; c the calibration curve obtained by plotting experimental ratio of analyte/isotope (A/I) as a function of expected ratio of A/I for mannitol; mannitol levels as measured in d CSF and e serum from three patients before and 30 min after intravenous injection (p < 0.05, Wilcoxon signed-rank test). Five independent experiments were performed for each sample to calculate the standard deviation (s.d.) as error bars. Data were shown as the mean ± s.d. (n = 5)

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