Fig. 3 | Nature Communications

Fig. 3

From: Plasmonic silver nanoshells for drug and metabolite detection

Fig. 3

Postoperative brain infection diagnosis based on glucose quantitation. Mass spectra of 0.5 μL of native CSF showing a sodium-adducted and b silver-adducted characteristic molecular peaks of glucose and mannitol; c the calibration curve obtained by plotting experimental ratio of analyte/isotope (A/I) as a function of expected ratio of A/I for glucose; d typical mass spectrum of glucose and its isotope as internal standards (A/I, 1/1). The isotope (IS) contained six 13C. Glucose levels as measured in CSF from the e infected patient and f uninfected control in consecutive 4 days. g Glucose levels in CSF samples using the particle-assisted LDI MS and h the corresponding ROC curve showing the diagnostic sensitivity and specificity. The optimized threshold (2.85 mM) according to the ROC curve was denoted by the dotted line. Five independent experiments were performed for each sample to calculate the standard deviation (s.d.) as error bars. Data were shown as the mean ± s.d. (n = 5)

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