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A narrative review of initial treatment for ischemic priapism

Abstract

Priapism is a rare condition characterized by prolonged and often painful penile erection unrelated to sexual stimulation. Ischemic priapism, the most common subtype, requires immediate attention to prevent irreversible damage to erectile tissue. This narrative review explores the initial management strategies for ischemic priapism. Intracavernosal phenylephrine injection and aspiration with or without irrigation are recommended as first-line treatments, with alternative options available depending on clinical settings and patient factors. While guidelines offer clear recommendations for priapism lasting more than 4 h, management of shorter-duration cases remains challenging due to limited evidence.

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Fig. 1: Diagram of the initial management of patient presenting with priapism.

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References

  1. Bivalacqua TJ, Allen BK, Brock G, Broderick GA, Kohler TS, Mulhall JP, et al. Acute ischemic priapism: an AUA/SMSNA guideline. J Urol. 2021;206:1114–21.

    Article  PubMed  Google Scholar 

  2. Kulmala RV, Lehtonen TA, Tammela TL. Priapism, its incidence and seasonal distribution in Finland. Scand J Urol Nephrol. 1995;29:93–6.

    Article  CAS  PubMed  Google Scholar 

  3. Eland IA, van der Lei J, Stricker BH, Sturkenboom MJ. Incidence of priapism in the general population. Urology. 2001;57:970–2.

    Article  CAS  PubMed  Google Scholar 

  4. Stein DM, Flum AS, Cashy J, Zhao LC, McVary KT. Nationwide emergency department visits for priapism in the United States. J Sex Med. 2013;10:2418–22.

    Article  PubMed  Google Scholar 

  5. Cintho Ozahata M, Page GP, Guo Y, Ferreira JE, Dinardo CL, Carneiro-Proietti ABF, et al. Clinical and genetic predictors of priapism in sickle cell disease: results from the recipient epidemiology and donor evaluation study III Brazil cohort study. J Sex Med. 2019;16:1988–99.

    Article  PubMed  Google Scholar 

  6. Adeyoju AB, Olujohungbe ABK, Morris J, Yardumian A, Bareford D, Akenova A, et al. Priapism in sickle-cell disease; incidence, risk factors and complications - an international multicentre study. BJU Int. 2002;90:898–902.

    Article  CAS  PubMed  Google Scholar 

  7. Broderick GA, Kadioglu A, Bivalacqua TJ, Ghanem H, Nehra A, Shamloul R. Priapism: pathogenesis, epidemiology, and management. J Sex Med. 2010;7:476–500. 1 Pt 2.

    Article  PubMed  Google Scholar 

  8. Muneer A, Cellek S, Dogan A, Kell PD, Ralph DJ, Minhas S. Investigation of cavernosal smooth muscle dysfunction in low flow priapism using an in vitro model. Int J Impot Res. 2005;17:10–8.

    Article  CAS  PubMed  Google Scholar 

  9. Ortaç M, Çevik G, Akdere H, Ermeç B, Kadıoğlu A. Anatomic and functional outcome following distal shunt and tunneling for treatment i̇schemic priapism: a single-center experience. J Sex Med. 2019;16:1290–6.

    Article  PubMed  Google Scholar 

  10. Pal DK, Biswal DK, Ghosh B. Outcome and erectile function following treatment of priapism: an institutional experience. Urol Ann. 2016;8:46–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Salonia A, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European Association of Urology guidelines on sexual and reproductive health—2021 update: male sexual dysfunction. Eur Urol. 2021;80:333–57.

    Article  PubMed  Google Scholar 

  12. Mantadakis E, Cavender JD, Rogers ZR, Ewalt DH, Buchanan GR. Prevalence of priapism in children and adolescents with sickle cell anemia. J Pediatr Hematol Oncol. 1999;21:518–22.

    Article  CAS  PubMed  Google Scholar 

  13. Fowler JE, Koshy M, Strub M, Chinn SK. Priapism associated with the sickle cell hemoglobinopathies: prevalence, natural history and sequelae. J Urol. 1991;145:65–8.

    Article  PubMed  Google Scholar 

  14. Kim SC, Seo KK, Oh CH. Corporeal blood gas changes according to duration of drug-induced prolonged erection. J Korean Med Sci. 1993;8:202–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Wakrim S, Ziouziou I, Ralph D, Khabbal Y. Penile Doppler ultrasound study in priapism: a systematic review. Prog Urol. 2022;32:61–9.

    Article  CAS  PubMed  Google Scholar 

  16. von Stempel C, Zacharakis E, Allen C, Ramachandran N, Walkden M, Minhas S, et al. Mean velocity and peak systolic velocity can help determine ischaemic and non-ischaemic priapism. Clin Radiol. 2017;72:611.e9–611.e16.

    Article  Google Scholar 

  17. Martin C, Cocchio C. Effect of phenylephrine and terbutaline on ischemic priapism: a retrospective review. Am J Emerg Med. 2016;34:222–4.

    Article  PubMed  Google Scholar 

  18. Sönmez MG, Öztürk Sönmez L, Taşkapu HH, Kara C, Dündar ZD, Göğer YE, et al. Etiological factors and management in priapism patients and attitude of emergency physicians. Arch Ital Urol Androl. 2017;89:203–7.

    Article  PubMed  Google Scholar 

  19. Bennett N, Mulhall J. Sickle cell disease status and outcomes of African-American men presenting with priapism. J Sex Med. 2008;5:1244–50.

    Article  PubMed  Google Scholar 

  20. Zacharakis E, Raheem AA, Freeman A, Skolarikos A, Garaffa G, Christopher AN, et al. The efficacy of the T-shunt procedure and intracavernous tunneling (snake maneuver) for refractory ischemic priapism. J Urol. 2014;191:164–8.

    Article  PubMed  Google Scholar 

  21. Capogrosso P, Dimitropolous K, Russo GI, Tharakan T, Milenkovic U, Cocci A. et al. Conservative and medical treatments of non-sickle cell disease-related ischemic priapism: a systematic review by the EAU Sexual and Reproductive Health Panel. Int J Impot Res. 2002;36:6–19.

    Article  Google Scholar 

  22. Lowe FC, Jarow JP. Placebo-controlled study of oral terbutaline and pseudoephedrine in management of prostaglandin E1-induced prolonged erections. Urology. 1993;42:51–3. discussion 53-54

    Article  CAS  PubMed  Google Scholar 

  23. Habous M, Elkhouly M, Abdelwahab O, Farag M, Madbouly K, Altuwaijri T, et al. Noninvasive treatments for iatrogenic priapism: Do they really work? A prospective multicenter study. Urol Ann. 2016;8:193–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Bochinski DJ, Deng DY, Lue TF. The treatment of priapism-when and how? Int J Impot Res. 2003;15:S86–90.

  25. Traish A, Kim NN, Moreland RB, Goldstein I. Role of alpha-adrenergic receptors in erectile function. Int J Impot Res. 2000;12:S48–63.

  26. Reed-Maldonado AB, Kim JS, Lue TF. Avoiding complications: surgery for ischemic priapism. Transl Androl Urol. 2017;6:657–65.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Wen CC, Munarriz R, McAuley I, Goldstein I, Traish A, Kim N. Management of ischemic priapism with high-dose intracavernosal phenylephrine: from bench to bedside. J Sex Med. 2006;3:918–22.

    Article  CAS  PubMed  Google Scholar 

  28. Muneer A, Minhas S, Freeman A, Kumar P, Ralph DJ. Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. J Sex Med. 2008;5:2152–9.

    Article  CAS  PubMed  Google Scholar 

  29. Sidhu AS, Wayne GF, Kim BJ, Anderson AGS, Cordon BH, Caso JR, et al. The hemodynamic effects of intracavernosal phenylephrine for the treatment of ischemic priapism. J Sex Med. 2018;15:990–6.

    Article  PubMed  Google Scholar 

  30. Virag R, Bachir D, Lee K, Galacteros F. Preventive treatment of priapism in sickle cell disease with oral and self-administered intracavernous injection of etilefrine. Urology. 1996;47:777–81. discussion 781

    Article  CAS  PubMed  Google Scholar 

  31. Cormio L, Nisén H, Ruutu M, Selvaggi FP. Etilefrine in the prevention of prolonged erection after diagnostic pharmacological stimulation. Ann Chir Gynaecol. 1996;85:247–50.

    CAS  PubMed  Google Scholar 

  32. Gbadoé AD, Atakouma Y, Kusiaku K, Assimadi JK. Management of sickle cell priapism with etilefrine. Arch Dis Child. 2001;85:52–3.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Keskin D, Cal C, Delibaş M, Ozyurt C, Günaydin G, Nazli O, et al. Intracavernosal adrenalin injection in priapism. Int J Impot Res. 2000;12:312–4.

    Article  CAS  PubMed  Google Scholar 

  34. Roberts JR, Price C, Mazzeo T. Intracavernous epinephrine: a minimally invasive treatment for priapism in the emergency department. J Emerg Med. 2009;36:285–9.

    Article  PubMed  Google Scholar 

  35. Mantadakis E, Ewalt DH, Cavender JD, Rogers ZR, Buchanan GR. Outpatient penile aspiration and epinephrine irrigation for young patients with sickle cell anemia and prolonged priapism. Blood. 2000;95:78–82.

    Article  CAS  PubMed  Google Scholar 

  36. Lee M, Cannon B, Sharifi R. Chart for preparation of dilutions of alpha-adrenergic agonists for intracavernous use in treatment of priapism. J Urol. 1995;153:1182–3.

    Article  CAS  PubMed  Google Scholar 

  37. El-Bahnasawy MS, Dawood A, Farouk A. Low-flow priapism: risk factors for erectile dysfunction. BJU Int. 2002;89:285–90.

    Article  CAS  PubMed  Google Scholar 

  38. Brindley GS. New treatment for priapism. Lancet. 1984;2:220–1.

    Article  CAS  PubMed  Google Scholar 

  39. Palagiri RDR, Chatterjee K, Jillella A, Hammond DA. A case report of hypertensive emergency and intracranial hemorrhage due to intracavernosal Phenylephrine. Hosp Pharm. 2019;54:186–9.

    Article  PubMed  Google Scholar 

  40. Constantine ST, Gopalsami A, Helland G. Recurrent priapism gone wrong: ST-elevation myocardial infarction and cardiogenic shock after penile corporal phenylephrine irrigation. J Emerg Med. 2017;52:859–62.

    Article  PubMed  Google Scholar 

  41. Davila HH, Parker J, Webster JC, Lockhart JL, Carrion RE. Subarachnoid hemorrhage as complication of phenylephrine injection for the treatment of ischemic priapism in a sickle cell disease patient. J Sex Med. 2008;5:1025–8.

    Article  PubMed  Google Scholar 

  42. deHoll JD, Shin PA, Angle JF, Steers WD. Alternative approaches to the management of priapism. Int J Impot Res. 1998;10:11–4.

    Article  CAS  PubMed  Google Scholar 

  43. Martínez Portillo FJ, Jünemann KP. New aspects in the treatment of priapism. Andrologia. 1999;31:53–8.

    Article  PubMed  Google Scholar 

  44. Martínez Portillo F, Hoang-Boehm J, Weiss J, Alken P, Jünemann K. Methylene blue as a successful treatment alternative for pharmacologically induced priapism. Eur Urol. 2001;39:20–3.

    Article  PubMed  Google Scholar 

  45. Rutchik S, Sorbera T, Rayford RW, Sullivan J. Successful treatment of recalcitrant priapism using intercorporeal injection of tissue plasminogen activator. J Urol. 2001;166:628.

    Article  CAS  PubMed  Google Scholar 

  46. Bschleipfer TH, Hauck EW, Diemer TH, Bitzer M, Kirkpatrick Ch J, Pust RA, et al. Heparin-induced priapism. Int J Impot Res. 2001;13:357–9.

    Article  CAS  PubMed  Google Scholar 

  47. Lin PH, Bush RL, Lumsden AB. Low molecular weight heparin-induced priapism. J Urol. 2004;172:263.

    Article  PubMed  Google Scholar 

  48. Ramstein JJ, Lee A, Cohen AJ, Mmonu NA, Rios N, Enriquez A, et al. Clinical outcomes of periprocedural antithrombotic therapy in ischemic priapism management. J Sex Med. 2020;17:2260–6.

    Article  PubMed  Google Scholar 

  49. Leong JY, Prebay ZJ, Ebbott D, Li M, Chung PH. Evaluating the management trends for priapism and assessing the risk of priapism after in-office intracavernosal injections: a cross-sectional analysis. Int J Impot Res. 2024; https://doi.org/10.1038/s41443-024-00861-2.

  50. Saffon Cuartas JP, Sandoval-Salinas C, Martínez JM, Corredor HA. Treatment of priapism secondary to drugs for erectile dysfunction. Adv Urol. 2019;2019:e6214921.

    Article  Google Scholar 

  51. Schifano N, Capogrosso P, Boeri L, Fallara G, Cakir OO, Castiglione F, et al. Medications mostly associated with priapism events: assessment of the 2015–2020 Food and Drug Administration (FDA) pharmacovigilance database entries. Int J Impot Res. 2024;36:50–4.

    Article  PubMed  Google Scholar 

  52. Koirala S, Penagaluri P, Smith C, Lippmann S. Priapism and risperidone. South Med J. 2009;102:1266–8.

    Article  PubMed  Google Scholar 

  53. Rezaee ME, Gross MS. Are we overstating the risk of priapism with oral phosphodiesterase type 5 inhibitors? J Sex Med. 2020;17:1579–82.

    Article  CAS  PubMed  Google Scholar 

  54. Galatti L, Fioravanti A, Salvo F, Polimeni G, Giustini SE. Interaction between tadalafil and itraconazole. Ann Pharmacother. 2005;39:200–200.

    Article  PubMed  Google Scholar 

  55. Hübler J, Szántó A, Könyves K. Methylene blue as a means of treatment for priapism caused by intracavernous injection to combat erectile dysfunction. Int Urol Nephrol. 2003;35:519–21.

    Article  PubMed  Google Scholar 

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The authors confirm responsibility for the following: study conception and design SL, MH, BA, FY; manuscript drafting SL; manuscript revision and finalization SL, MH, BA, FY. Supanut Lumbiganon, SL. Muhammed A Moukhtar Hammad, MH. Babak Azad, BA. Faysal A Yafi, FY.

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Correspondence to Faysal A. Yafi.

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Lumbiganon, S., Moukhtar Hammad, M.A., Azad, B. et al. A narrative review of initial treatment for ischemic priapism. Int J Impot Res (2024). https://doi.org/10.1038/s41443-024-00951-1

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