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Premature ejaculation among men with erectile dysfunction—findings from a real-life cross-sectional study

International Journal of Impotence Research volume 35, pages 558–563 (2023)Cite this article

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The Original Article was published on 27 September 2022

Abstract

Concomitant sexual disorders have progressively shown increased prevalence in men at first outpatient presentation. We sought to i) estimate the prevalence of unreported premature ejaculation (PE) in a homogenous cohort of 1258 men seeking first medical help for erectile dysfunction (ED) as their primary compliant; ii) compare the baseline sociodemographic and clinical characteristics of men with only ED(ED-only) compared to those with ED and PE(ED + PE); and, iii) investigate the likelihood of detecting PE among men self-reporting only ED over a 16-year period at a single tertiary-referral centre. Descriptive statistics compared sociodemographic and clinical characteristics between ED-only patients and those with unreported concomitant primary/secondary PE(ED + PE). Logistic regression models predicted the risk of having ED + PE at baseline. Local polynomial regression models graphically explored the probability of reporting PE among ED men with ≤40 vs. 41–60 vs. >60 years over the analysed timeframe. Of all, 932 (74.1%) were ED-only and 326 (25.9%) ED + PE patients, respectively. ED + PE patients were younger, presented with fewer comorbidities, and lower rates of severe ED (all p ≤ 0.04). At multivariable logistic regression analysis, younger age (OR:0.98) and low sexual desire/interest (OR:1.54) were independently associated with ED + PE at first clinical assessment (all p = 0.03). The likelihood of detecting unreported concomitant primary/secondary PE among patients complaining of only ED at first presentation worrisomely increased among younger and middle-aged men over the last 16 years.

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Fig. 1: Local polynomial regression models showing the probability of reporting ED + PE over the analysed time frame.

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Authors and Affiliations

  1. Division of Experimental Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Milan, Italy

    Simone Cilio, Edoardo Pozzi, Giuseppe Fallara, Federico Belladelli, Christian Corsini, Alessia d’Arma, Francesco Montorsi & Andrea Salonia

  2. Department of Neurosciences, Reproductive Sciences and Odontostomatology, Urology Unit, University of Naples “Federico II”, Naples, Italy

    Simone Cilio, Ciro Imbimbo & Vincenzo Mirone

  3. University Vita-Salute San Raffaele, Milan, Italy

    Edoardo Pozzi, Giuseppe Fallara, Federico Belladelli, Christian Corsini, Francesco Montorsi & Andrea Salonia

  4. Department of Urology, Foundation IRCCS Ca’ Granda -Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

    Luca Boeri

  5. Department of Urology, Circolo & Fondazione Macchi Hospital -ASST Sette Laghi, Varese, Italy

    Paolo Capogrosso

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Contributions

Conception and design of the study: SC, EP, GF, AS. Data acquisition: FB, AD, LB. Analysis and interpretation of data: SC, EP, GF, AS. Drafting the manuscript: CI, VM, FM. Style revision: CC, PC, AS. All authors revised the manuscript and read and approved the version submitted.

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Correspondence to Andrea Salonia.

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The authors declare no competing interests.

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Data collection followed the principles outlined in the Declaration of Helsinki; all patients had signed an informed consent agreeing to deliver their own anonymous information for future studies. The study was approved by our local ethics committee.

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Cilio, S., Pozzi, E., Fallara, G. et al. Premature ejaculation among men with erectile dysfunction—findings from a real-life cross-sectional study. Int J Impot Res 35, 558–563 (2023). https://doi.org/10.1038/s41443-022-00601-4

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