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Majority of men with premature ejaculation do not receive pharmacotherapy


Premature ejaculation is the most common male sexual dysfunction, with therapies including selective serotonin reuptake inhibitors, clomipramine, topical anesthetics, dapoxetine and tramadol. However, it is currently unknown how many men are receiving pharmacotherapy for premature ejaculation. Using the TriNetX Research network, a large multicenter database containing over 75 million patient records from hospitals across the United States, we evaluated prescribing patterns for treatment of premature ejaculation and assessed variations in prescription patterns among patients from 2015–2021. In addition, we examined if the prescription patterns for tramadol changed with the establishment of Prescription Drug Monitoring Programs. We found that most men (51.7%) were not receiving any pharmacotherapy for premature ejaculation. However, men with mental health disorders, were more likely (56.0%), to have been treated than those without (44.4%). On further analysis, men with mental health diagnoses were significantly more likely to be treated with Selective Serotonin Reuptake Inhibitors (45.0 vs 32.2%) and Tramadol (5.1% vs 3.5%). While the pharmacotherapy for premature ejaculation has been well researched, our findings revealed that most patients diagnosed with premature ejaculation do not receive pharmacotherapy and that patients are more likely to be prescribed premature ejaculation medications if they have a pre-existing mental health diagnosis.

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Fig. 1: Pharmacotherapy for Premature Ejaculation.


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IZ was responsible for project conception/design; literature review; manuscript drafting/revisions. SN was responsible for project conception/design; literature review; statistical analysis; manuscript drafting/revisions; tabulation of data. CC helped with tabulation of data. NK helped with manuscript drafting/revisions. VM was responsible for project conception/design; literature review; statistical analysis; manuscript drafting/revisions. RR was responsible for project conception/design; manuscript drafting/revisions.

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Correspondence to Ranjith Ramasamy.

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The authors declare no competing interests.

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Zucker, I., Nackeeran, S., Kulkarni, N. et al. Majority of men with premature ejaculation do not receive pharmacotherapy. Int J Impot Res (2022).

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