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His452Tyr 5-HT2A polymorphism and intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation

International Journal of Impotence Research volume 35, pages 103–106 (2023)Cite this article

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Abstract

Lifelong premature ejaculation (LPE) may have heritable components. Selective serotonin reuptake inhibitors have been proven effective in prolonging intravaginal ejaculation latency time (IELT). Given that serotonergic pathways are involved in the ejaculation mechanism, we aimed to investigate whether His452Tyr, also known as the C1354T (RS6314) polymorphism of the 5-HT2A receptor, contributes to LPE pathogenesis and IELT differences among patients with LPE. Dutch Caucasian men with LPE (n = 65) attending the Outpatient Department of Neurosexology, HagaZiekenhuis for drug treatment for LPE in 2009 were selected and included in this case–control study. IELT during coitus was measured using a stopwatch, and all men were genotyped for the His452Tyr polymorphism. Analysis of variance (ANOVA) was performed to determine the association between the genotypes and IELTs. Mean IELTs with standard deviations were 29.7 (±20.9), 31.5 (±14.7), and 26.0 s, and the frequencies were 83.1%, 15.4%, and 1.5% for the CC, CT, and TT groups, respectively, with an average IELT of 29.9 s. No difference in mean IELT was observed between these groups. In the affected group, the frequencies of alleles C and T were 90.8% and 9.2%, respectively; whereas those among randomly selected European Caucasian male controls (n = 503) from the CEPH database were of 92.0% and 8.0%, respectively. No significant difference was observed between the groups. Therefore, no correlation was found between the His452Tyr polymorphism and IELT distribution in patients with LPE.

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Fig. 1: Distribution of IELT in LPE patients (N = 65).

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Acknowledgements

The authors thank Marcel D. Waldinger MD Ph.D., who died on May 1, 2019, for his contribution to this study. The authors also thank the Department of Complex Genetics of Utrecht University for making their laboratory available.

Funding

This study was made possible by funding from Prof. Dr. Marcel Waldinger foundation, The Netherlands.

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Author notes

  1. These authors contributed equally: J.J. van Raaij, K. H. Hua.

Authors and Affiliations

  1. Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands

    J. J. van Raaij, K. H. Hua, F. de Vries & Paddy K. C. Janssen

  2. Department of Clinical Pharmacy and Toxicology, VieCuri Medical Centre, Venlo, The Netherlands

    J. J. van Raaij & Paddy K. C. Janssen

  3. Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands

    F. de Vries

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  1. J. J. van Raaij
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  4. Paddy K. C. Janssen
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Contributions

PKCJ carried out the experiments and took full responsibility for data processing and methodology. KHH took the lead in writing the paper. JJR helped shape the research, analysis, and paper. FV provided critical feedback.

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Correspondence to Paddy K. C. Janssen.

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Competing interests

FV supervises two Ph.D. students who are employed by F. Hoffmann la Roche Ltd. (Basel, Switzerland; Welwyn Garden City, UK). The topics of their Ph.D. theses are not related to the current article. FV has not received any fees or reimbursements for his supervision.

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van Raaij, J.J., Hua, K.H., de Vries, F. et al. His452Tyr 5-HT2A polymorphism and intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. Int J Impot Res 35, 103–106 (2023). https://doi.org/10.1038/s41443-021-00489-6

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