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Myointimoma of the penis

International Journal of Impotence Research volume 33, pages 583–586 (2021)Cite this article

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Abstract

Myointimoma is an uncommon, benign soft-tissue tumor derived from the intimal cells of blood vessels. Since little is known about this rare tumor entity, our aim is to describe an additional case and to perform the first literature review on this topic. A 49-year-old Caucasian man presented with a 12-month history of a palpable, firm, solitary lesion involving the glans penis. On physical examination, there was a 1 cm palpable, endophytic well-circumscribed nodule located to the left side of glans penis, close to the coronal sulcus, with disease-free external urethral orifice. The patient was submitted to complete excisional biopsy. A skin rhombus measuring 1.1 × 0.8 × 0.3 cm was removed and the biopsy sample, fixed in 10% formaldehyde, sent to Pathology. At the 18-month follow-up visit, the patient was clinically disease free. Histopathology revealed a multinodular intravascular proliferation of the corpus spongiosum. This myointimal proliferation comprised bland predominantly spindle cells in an abundant fibromyxoid stroma. Immunostains for smooth muscle actin (1A4), cytokeratins (AE1/AE3, CAM5.2), and CD34 were carried out using the avidin-biotin complex (ABC) immunoperoxidase method. Lesional cells displayed positivity for smooth muscle actin and negativity for cytokeratins and CD34. Myointimoma is confirmed to be a penile benign lesion that may be adequately treated with excisional biopsy. Even after incomplete or marginal removal, the penile lesion has been shown to remain stable overtime or regress. Differential diagnosis is essential to exclude similar histologic entities that could be more aggressive or have possible systemic implications.

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Fig. 1: Pathological features of penile myointimoma.

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References

  1. Fetsch JF, Brinsko RW, Davis CJ Jr, Mostofi FK, Sesterhenn IA. A distinctive myointimal proliferation (‘myointimoma’) involving the corpus spongiosum of the glans penis: a clinicopathologic and immunohistochemical analysis of 10 cases. Am J Surg Pathol. 2000;24:1524–30.

    Article  CAS  Google Scholar 

  2. WHO. Classification of tumors of the urinary system and male genital organs. Moch H, Humphrey PA, Ulbright TM, Reuter V, editors. Lyon: IARC; 2016.

  3. Robbins JB, Kohler S. Penile nodule in a 54-year-old man: a case of a myointimoma. J Am Acad Dermatol. 2005;53:1084–6.

    Article  Google Scholar 

  4. Vardar E, Gunlusoy B, Arslan M, Kececi S. Myointimoma of the glans penis. Pathol Int. 2007;57:158–61.

    Article  Google Scholar 

  5. McKenney JK, Collins MH, Carretero AP, Boyd TK, Redman JF, Parham DM. Penile myointimoma in children and adolescents: a clinicopathologic study of 5 cases supporting a distinct entity. Am J Surg Pathol. 2007;31:1622–6.

    Article  Google Scholar 

  6. Turner BM, Reith JD, Al-Quran SZ. Penile myointimoma. J Cutan Pathol. 2009;36:817–9.

    Article  Google Scholar 

  7. Monsálvez V, Rodríguez-Peralto JL, Fuertes L, Garrido C, López-Gómez S. Myointimoma: a rare tumor of the penis. Actas Dermosifiliogr. 2009;100:511–2.

    Article  Google Scholar 

  8. Tanriverdi HI, Yılmaz O, Neşe N, Taneli C, Genc A. Myointimoma of the glans penis. J Pediatr Surg Case Rep. 2019;44:101189. https://doi.org/10.1016/j.epsc.2019.101189.

    Article  Google Scholar 

  9. Dehner LP, Smith BH. Soft tissue tumors of the penis. A clinicopathologic study of 46 cases. Cancer. 1970;25:1431–47.

    Article  CAS  Google Scholar 

  10. Hey A. 2 rare nonepithelial benign tumors of the penis. Pathologe. 1984;5:286–8.

    CAS  PubMed  Google Scholar 

  11. Montgomery EA, Fetsch JF. Tumors and tumefactions of peripheral vessels. In: Stebens WE, Lie JT, editors. Vascular pathology. London: Chapman & Hall Medical; 1995. p. 739–85.

  12. Redman JF, Liang X, Ferguson MA, Savelli VH. Leiomyoma of the glans penis in a child. J Urol. 2000;164:791.

    Article  CAS  Google Scholar 

  13. Val-Bernal JF, Garijo MF. Solitary cutaneous myofibroma of the glans penis. Am J Dermatopathol. 1996;18:317–21.

    Article  CAS  Google Scholar 

  14. Enzinger FM, Zhang R. Plexiform fibrohistiocytic tumor presenting in children and young adults: an analysis of 65 cases. Am J Surg Pathol. 1988;12:818–26.

    Article  CAS  Google Scholar 

  15. Hollowood K, Holley MP, Fletcher CDM. Plexiform fibrohistiocytic tumour: clinicopathological, immunohistochemical and ultrastructural analysis in favour of a myofibroblastic lesion. Histopathology. 1991;19:503–13.

    Article  CAS  Google Scholar 

  16. Daimaru Y, Hashimoto H, Enjoji M. Myofibromatosis in adults (adult counterpart of infantile myofibromatosis). Am J Surg Pathol. 1989;13:859–65.

    Article  CAS  Google Scholar 

  17. Chung EB, Enzinger FM. Infantile myofibromatosis. Cancer. 1981;48:1807–18.

    Article  CAS  Google Scholar 

  18. Montgomery EA, Meis JM. Nodular fasciitis: its morphologic spectrum and immunohistochemical profile. Am J Surg Pathol. 1991;15:942–8.

    Article  CAS  Google Scholar 

  19. Chi AC, Dunlap WS, Richardson MS, Neville BW. Intravascular fasciitis: report of an intraoral case and review of the literature. Head Neck Pathol. 2012;6:140–5.

    Article  Google Scholar 

  20. Morales MM, Anacleto A, Leal JC, Carvalho S, Del’ArcoII J. Intravascular leiomyoma with heart extension. Clinics. 2012;67:83–7.

    Article  Google Scholar 

  21. Salomao DR, Nascimento AG. Plexiform fibrohistiocytic tumor with systemic metastases: a case report. Am J Surg Pathol. 1997;21:469–76.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Urology, Careggi Hospital, University of Florence, Largo Brambilla 3, 50134, Florence, Italy

    Gianmartin Cito, Luca Gemma, Andrea Cocci, Marco Carini & Andrea Minervini

  2. Pathology Section, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy

    Raffaella Santi, Ilaria Camilla Galli & Gabriella Nesi

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  1. Gianmartin Cito
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  2. Raffaella Santi
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Correspondence to Gianmartin Cito.

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Cito, G., Santi, R., Gemma, L. et al. Myointimoma of the penis. Int J Impot Res 33, 583–586 (2021). https://doi.org/10.1038/s41443-020-0316-7

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