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About the drawback of collagenase

International Journal of Impotence Research volume 33, pages 570–571 (2021)Cite this article

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Peyronie’s disease (PD) is a disease that results in a formation of a fibrotic plaque of the tunica albuginea, that can lead to a number of penile deformities such as curvature, shortening, narrowing, hour-glass deformity and/or hinge defect. PD usually affects men in the 50s–60s and the estimated incidence varies from 3 to 9% [1], with peaks up to 20.3% in selected populations, as in diabetic patients [2]. The etiology of PD is still unknown, but the most accepted hypothesis is that vascular microtrauma during sexual intercourse releases an uncontrolled inflammatory reaction in genetically susceptible men [3]. Besides anatomical deformities, PD can affect sexual function and satisfaction, quality of life, and the existing partner relationship, and may be accompanied by lowered sense of self-worth, feelings of isolation, and symptoms of depression and anxiety [4].

Historically, many drugs have been proposed as non-surgical treatment of PD, such as oral drugs (pentoxifylline, L-arginine, colchicine), intraplaque injections or iontophoresis (corticosteroids, interferon, verapamil), and even low intensity shockwave therapy. None of them have shown a clear benefit against placebo in curvature correction [5,6,7,8], so surgery remained the gold standard of treatment of PD, even though the risks of penile shortening, erectile dysfunction, penile numbness, recurrence of curvature, possible palpable stitches under the skin, and potential need of circumcision at the time of surgery [9].

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Authors and Affiliations

  1. Department of Urology, Hospital Universitario 12 de Octubre, Madrid, Spain

    Borja García-Gómez & Javier Romero-Otero

  2. Department of Urology, Hospital Universitario HM Montepríncipe, Boadilla del Monte, Madrid, Spain

    Borja García-Gómez & Javier Romero-Otero

  3. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain

    Borja García-Gómez & Javier Romero-Otero

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  1. Borja García-Gómez
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  2. Javier Romero-Otero
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Correspondence to Javier Romero-Otero.

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García-Gómez, B., Romero-Otero, J. About the drawback of collagenase. Int J Impot Res 33, 570–571 (2021). https://doi.org/10.1038/s41443-020-0286-9

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