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Erectile dysfunction among patients with chronic brucellosis

International Journal of Impotence Research volume 30, pages 230–236 (2018)Cite this article

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Abstract

Objective

Only a single study investigated erectile dysfunction (ED) among patients with chronic brucellosis without including a control group. Our study objective was to determine the prevalence of ED among patients with chronic brucellosis compared to normal subjects, and to explore the predictors of ED.

Materials and methods

We included 93 chronic brucellosis patients and 92 subjects as a control, from June 2013 to August 2017. Chronic brucellosis was diagnosed based on persistent symptoms for ≥1 year with positive immunoglobulin G antibody titer (≥1:160) by standard tube agglutination test; the mean duration was 21 ± 6.2 months. Clinical evaluation (including an Arabic validated version of the five-item International Index of Erectile Function to diagnose ED; score of 5–21 was diagnostic), imaging studies (including scrotal ultrasonography) and laboratory investigations (including estimation of fasting serum level of glucose (after fasting for 8 h), lipids profile (after fasting for 14 h), and serum level of testosterone) were conducted. A fasting serum glucose level of ≥ 7 mmol/L defined diabetes mellitus (DM). Predictors of ED were identified using multivariate analysis (binary logistic regression).

Results

The mean age of patients was 35.4 ± 13.7 years; 24.7% of them had DM, while low serum level of testosterone was detected among 54.8%. Among the patients, ED was significantly more frequent compared to the control subjects (69.9% vs. 19.6%, p < 0.001). Low serum level of testosterone (OR 4.8, 95% CI 1.7–29.3, p 0.008), and DM (OR 3.5, 95% CI 1.2–34.6, p 0.011) were the predictors of ED among the patients.

Conclusions

The prevalence of ED among patients with chronic brucellosis is high. Low serum level of testosterone and DM are associated with ED among such patients.

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Authors and Affiliations

  1. Department of Urology, Assiut University, Assiut, Egypt

    Ahmed S. Safwat

  2. Department of Tropical Medicine and Gastroenterology, Assiut University, Assiut, Egypt

    Ahmad F. Hasanain

  3. Department of Dermatology and Andrology (Andrology Unit), Assiut University, Assiut, Egypt

    Ali Mahran

  4. Department of Biochemisrty, Assiut University, Assiut, Egypt

    Sally Bakkar

  5. Department of Diagnostic Radiology, Assiut University, Assiut, Egypt

    Sherif Abdel-Aal

  6. Department of Microbiology and Immunology, Assiut University, Assiut, Egypt

    Amany Nafee

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  1. Ahmed S. Safwat
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Correspondence to Ahmed S. Safwat.

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Safwat, A.S., Hasanain, A.F., Mahran, A. et al. Erectile dysfunction among patients with chronic brucellosis. Int J Impot Res 30, 230–236 (2018). https://doi.org/10.1038/s41443-018-0068-9

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  • DOI: https://doi.org/10.1038/s41443-018-0068-9

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