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The effect of low vitamin D status on sexual functioning and depressive symptoms in apparently healthy men: a pilot study

International Journal of Impotence Research volume 30, pages 224–229 (2018)Cite this article

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Abstract

Hypovitaminosis D is associated with sexual dysfunction in apparently healthy women and with erectile dysfunction in men with the presence of concomitant disorders. This study was aimed at investigating sexual functioning and depressive symptoms in young men with low vitamin D status. The study included 15 apparently healthy men (18–40 years old) with vitamin D deficiency (group A), 16 subjects with vitamin D insufficiency (group B), and 16 men with normal vitamin D status (group C). All participants of the study completed questionnaires investigating their sexual function (the International Index of Sexual Function-15—IIEF-15 for heterosexual men), as well as the presence and severity of depressive symptoms (Beck Depression Inventory-Second Edition—BDI-II). Compared with healthy men, subjects with vitamin D deficiency obtained lower scores for erectile function, orgasmic function, and sexual desire, while individuals with vitamin D insufficiency lower scores only for erectile function. Erectile dysfunction was more prominent in group A than group B. The total BDI-II score was higher in group A than in the other study groups. The results of the study suggest that low vitamin D status impairs male sexual functioning and severity of sexual dysfunction correlates with the degree of hypovitaminosis D.

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References

  1. Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol. 2014;810:106–19.

    PubMed  Google Scholar 

  2. Lai YH, Fang TC. The pleiotropic effect of vitamin D. ISRN Nephrol. 2013;2013:898125.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin. 2008;24:139–49.

    Article  CAS  PubMed  Google Scholar 

  4. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutr Res Rev. 2009;22:82–92.

    Article  CAS  PubMed  Google Scholar 

  5. Guillot X, Semerano L, Saidenberg-Kermanach N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine. 2010;77:552–7.

    Article  CAS  PubMed  Google Scholar 

  6. Haussler MR. Vitamin D receptors: nature and function. Annu Rev Nutr. 1986;6:527–62.

    Article  CAS  PubMed  Google Scholar 

  7. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–81.

    Article  CAS  PubMed  Google Scholar 

  8. Pilz S, Grübler M, Gaksch M, Schwetz V, Trummer C, Hartaigh BÓ, et al. Vitamin D and mortality. Anticancer Res. 2016;36:1379–87.

    CAS  PubMed  Google Scholar 

  9. Wranicz J, Szostak-Węgierek D. Health outcomes of vitamin D. Part II. Role in prevention of diseases. Rocz Panstw Zakl Hig. 2014;65:273–9.

    CAS  PubMed  Google Scholar 

  10. Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2016;13:404–17.

    Article  CAS  PubMed  Google Scholar 

  11. Cutolo M, Pizzorni C, Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun Rev. 2011;11:84–87.

    Article  CAS  PubMed  Google Scholar 

  12. Caretta N, de Kreutzenberg SV, Valente U, Guarneri G, Ferlin A, Avogaro A, et al. Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes. Endocrine. 2016;53:831–8.

    Article  CAS  PubMed  Google Scholar 

  13. Barassi A, Pezzilli R, Colpi GM, Corsi Romanelli MM, Melzi d’Eril GV. Vitamin D and erectile dysfunction. J Sex Med. 2014;11:2792–2800.

    Article  CAS  PubMed  Google Scholar 

  14. Farag YM, Guallar E, Zhao D, Kalyani RR, Blaha MJ, Feldman D, et al. Vitamin D deficiency is independently associated with greater prevalence of erectile dysfunction: the National Health and Nutrition Examination Survey (NHANES) 2001-4. Atherosclerosis. 2016;252:61–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Kidir V, Altuntas A, Inal S, Akpinar A, Orhan H, Sezer MT. Sexual dysfunction in dialysis patients: does vitamin D deficiency have a role? Int J Clin Exp Med. 2015;8:22491–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Grant WB. Vitamin D deficiency may explain the link between back pain and erectile dysfunction. Spine. 2013.

  17. Canguven O, Talib RA, El Ansari W, Yassin DJ, Al Naimi A. Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men. Aging Male. 2017;11:1–8.

    Google Scholar 

  18. Bellastella G, Maiorino MI, Olita L, Capuano A, Rafaniello C, Giugliano D, et al. Vitamin D deficiency in type 2 diabetic patients with hypogonadism. J Sex Med. 2014;11:536–42.

    Article  CAS  PubMed  Google Scholar 

  19. Krysiak R, Gilowska M, Okopień B. Sexual function and depressive symptoms in young women with low vitamin D status: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2016;204:108–12.

    Article  CAS  PubMed  Google Scholar 

  20. Krysiak R, Szkróbka W, Okopień B. The effect of l-thyroxine treatment on sexual function and depressive symptoms in men with autoimmune hypothyroidism. Pharmacol Rep. 2017;69:432–7.

    Article  CAS  PubMed  Google Scholar 

  21. Rosen RC, Cappelleri JC, Gendrano N 3rd. The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res. 2002;14:226–44.

    Article  CAS  PubMed  Google Scholar 

  22. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology. 1999;54:346–51.

    Article  CAS  PubMed  Google Scholar 

  23. Beck AT, Steer RA, Brown GK. BDI-II: beck depression inventory manual. 2nd edn. San Antonio: Psychological Corporation; 1996.

  24. American Psychiatric Association. Diagnostic and statistical manual of mental disorders—DSM-IV-TR. 4th edn. Washington: American Psychiatric Publishing; 1994.

    Google Scholar 

  25. Andrukhova O, Slavic S, Zeitz U, Riesen SC, Heppelmann MS, Ambrisko TD, et al. Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol. 2014;28:53–64.

    Article  CAS  PubMed  Google Scholar 

  26. Molinari C, Uberti F, Grossini E, Vacca G, Carda S, Invernizzi M, Cisari C, et al. 1α,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem. 2011;27:661–8.

    Article  CAS  PubMed  Google Scholar 

  27. Anic GM, Albanes D, Rohrmann S, Kanarek N, Nelson WG, Bradwin G, et al. Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES. Clin Endocrinol (Oxf). 2016;85:258–66.

    Article  CAS  Google Scholar 

  28. Murdoch GH, Rosenfeld MG. Regulation of pituitary function and prolactin production in the GH4 cell line by vitamin D. J Biol Chem. 1981;256:4050–3.

    CAS  PubMed  Google Scholar 

  29. Podlasek CA, Mulhall J, Davies K, Wingard CJ, Hannan JL, Bivalacqua TJ, et al. Translational perspective on the role of testosterone in sexual function and dysfunction. J Sex Med. 2016;13:1183–98.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Corona G, Isidori AM, Aversa A, Burnett AL, Maggi M. Endocrinologic control of men’s sexual desire and arousa/erection. J Sex Med. 2016;13:317–37.

    Article  PubMed  Google Scholar 

  31. Lv WS, Zhao WJ, Gong SL, Fang DD, Wang B, Fu ZJ, et al. Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis. J Endocrinol Invest. 2015;38:513–8.

    Article  CAS  PubMed  Google Scholar 

  32. Jung CH, Jung SH, Kim KJ, Kim BY, Kim CG, Kang SK, et al. The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus. Diab Vasc Dis Res. 2015;12:342–51.

    Article  CAS  PubMed  Google Scholar 

  33. Adler UC, Marques AH, Calil HM. Inflammatory aspects of depression. Inflamm Allergy Drug Targets. 2008;7:19–23.

    Article  CAS  PubMed  Google Scholar 

  34. Lips P. Vitamin D physiology. Prog Biophys Mol Biol. 2006;92:4–8.

    Article  CAS  PubMed  Google Scholar 

  35. Rausch-Fan X, Leutmezer F, Willheim M, Spittler A, Bohle B, Ebner C, et al. Regulation of cytokine production in human peripheral blood mononuclear cells and allergen-specific Th cell clones by 1 alpha,25-dihydroxyvitamin D-3. Intern Arch Allergy Immunol. 2002;128:33–41.

    Article  CAS  Google Scholar 

  36. Cass WA, Smith MP, Peters LE. Calcitriol protexts against the dopamine- and serotonin-depleting effects of neurotoxic dosese of methamphetamine. Ann N Y Acad Sci. 2006;1074:261–71.

    Article  CAS  PubMed  Google Scholar 

  37. Gozdzik A, Barta JL, Weir A, Cole DE, Vieth R, Whiting SJ, et al. Serum 25-hydroxyvitamin D concentrations fluctuate seasonally in young adults of diverse ancestry living in Toronto. J Nutr. 2010;140:2213–20.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland

    Robert Krysiak & Bogusław Okopień

  2. Oncology Ward, Beskid Oncology Centre—John Paul II Municipal Hospital in Bielsko-Biała, Bielsko-Biała, Poland

    Anna Szwajkosz

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  1. Robert Krysiak
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  2. Anna Szwajkosz
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  3. Bogusław Okopień
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Correspondence to Robert Krysiak.

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The authors declare that they have no conflict of interest.

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The study was approved by the Bioethical Committee of the Medical University of Silesia.

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Krysiak, R., Szwajkosz, A. & Okopień, B. The effect of low vitamin D status on sexual functioning and depressive symptoms in apparently healthy men: a pilot study. Int J Impot Res 30, 224–229 (2018). https://doi.org/10.1038/s41443-018-0041-7

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