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Acquired premature ejaculation in Parkinson’s disease and possible mechanisms

International Journal of Impotence Researchvolume 30pages153157 (2018) | Download Citation

Abstract

Premature ejaculation (PE) has been reported in 40.6–51.5% of men affected by Parkinson’s disease (PD), however, this non-motor sexual complaint has not been studied in detail. We describe eight PD patients who asked for a sexological consultation between 2008 and 2014 because of a new-onset of PE. They were diagnosed with acquired PE (APE) according to the DSM-V criteria and the International Society for Sexual Medicine (ISSM) committee. Patients’ demographic, medical and sexual related data were retrieved and studied. The average age of onset of PD was 53.3 ± 12.7 years (range 38–77 years) and the sexual problem appeared 4.0 ± 3.1 years later. The mean intravaginal ejaculation latency (IELT) before APE onset was 7.3 (range 2–20) min. Interestingly, the ejaculatory disorder appeared abruptly, characterized by a dramatically shortened IELT in all patients, while in three of the cases ejaculation occurred before vaginal penetration, hampering sexual intercourse. Some patients had 2 additional sexual problems, (four with erectile dysfunctions, five with libido changes: increased desire in four and reduced in one). In this case series of PD patients with APE, the ejaculatory dysfunction developed when patients were on antiparkinsonian medications, suggesting a possible medication effect.

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Author information

Affiliations

  1. Department of Neurology and Sagol Neuroscience Center, The Movement Disorders Institute, Tel Aviv, Israel

    • Gila Bronner
    • , Simon Israeli-Korn
    • , Sharon Hassin-Baer
    •  & Gilad Yahalom
  2. Department of Urology, Sexual Medicine Center, Chaim Sheba Medical Center, Tel- Hashomer, Israel

    • Gila Bronner
  3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    • Sharon Hassin-Baer
    •  & Gilad Yahalom

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Gilad Yahalom.

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DOI

https://doi.org/10.1038/s41443-018-0034-6

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