No previous studies have investigated the prevalence of latent tuberculosis infection (LTBI) among patients with erectile dysfunction (ED) or its contribution to the development of high-grade ED through a process of chronic inflammation-induced atherosclerosis. The aim of this study was to determine the frequency of LTBI among patients with erectile dysfunction and to explore the contribution of LTBI to high-grade ED. For all the study sample, clinical evaluation, imaging studies, and laboratory investigations were provided. Evaluation included, but was not confined to, scrotal ultrasonography, tuberculin skin test, and QuantiFERON-TB Gold test. The study sample mean ± SD age was 47.9 ± 13.6 years. Approximately 30% of the patients had LTBI and 43% had high-grade ED. After a multivariate analysis, it was found that older age (≥40 years) (OR, 5.2; 95% CI, 1.9–54.6; p 0.004), metabolic syndrome (MS) (OR, 3.4; 95% CI, 1.3–48.2; p 0.016), and LTBI (OR, 4.1; 95% CI, 1.7–61.3; p 0.021) were significantly, independently associated with high-grade ED as opposed to low-grade ED. In conclusion, the prevalence of LTBI among patients with high-grade ED is higher than among those with low-grade ED. In addition to LTBI, older age and MS are associated with high-grade ED as opposed to low-grade ED.
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A.F.A.H.: Concepts, design, definition of intellectual content, literature search, clinical studies, data acquisition, data analysis, statistical analysis, manuscript preparation, manuscript editing, and guarantor. A.M.A.M. and A.S.S.: Literature search, clinical studies, data acquisition, and manuscript review. A.M.A.N.: Definition of intellectual content, experimental studies, data acquisition, and manuscript editing. A.A.H.Z.: literature search, clinical studies, data acquisition, data analysis, and manuscript editing. S.M.A.-A.: Data acquisition. S.M.B.: Experimental studies, data acquisition, and manuscript review. A.E.I.A.: Statistical analysis, manuscript preparation, manuscript editing, and manuscript review.
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Hasanain, A.F.A., Mahran, A.M.A., Safwat, A.S. et al. Latent tuberculosis infection among patients with erectile dysfunction. Int J Impot Res 30, 36–42 (2018). https://doi.org/10.1038/s41443-017-0004-4