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Low-intensity extracorporeal shock wave therapy for erectile dysfunction after radical prostatectomy: a review of preclinical studies

Abstract

Low-intensity extracorporeal shock wave therapy (LI-ESWT) is a novel treatment for erectile dysfunction (ED). Its ability to improve erectile function has been shown in patients with vasculogenic ED by many randomized-controlled trials against sham procedures. However, the role of LI-ESWT in ED caused by radical prostatectomy (RP) is still questionable because this type of ED was excluded from nearly all clinical studies; it has been investigated in only a few small single-arm trials. This review summarizes preclinical studies on mechanisms of action of LI-ESWT for ED and neurological diseases to explore the potential of this treatment for nerve-impaired ED after RP.

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Acknowledgments

This work was supported by the Science and Technology Foundation of the Sichuan Province (2014JY0183 to Y.-p.L.) and the Science and Technology Foundation of the Chengdu City (2014-HM01-00301-SF to Y.-p.L.).

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Correspondence to Rui Gao or Yi-ping Lu.

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The authors declare that they have no competing interests.

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Zi-jun Zou and Jia-yu Liang contributed equally to this work.

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Zou, Zj., Liang, Jy., Liu, Zh. et al. Low-intensity extracorporeal shock wave therapy for erectile dysfunction after radical prostatectomy: a review of preclinical studies. Int J Impot Res 30, 1–7 (2018). https://doi.org/10.1038/s41443-017-0002-6

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