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The roles of long noncoding RNA NEAT1 in cardiovascular diseases

Hypertension Research volume 47, pages 735–746 (2024)Cite this article

Abstract

The morbidity of cardiovascular diseases (CVDs) gradually increases worldwide. Long noncoding RNAs (lncRNAs) are a large class of non-(protein)-coding RNAs with lengths beyond 200 nucleotides. Increasing evidence suggests that lncRNA NEAT1 plays important roles in the pathogenesis of CVDs, such as myocardial infarction, heart failure, myocardial ischemia-reperfusion (I/R) injury, atherosclerosis, hypertension, cardiomyopathy, and others. We summarized the current studies of NEAT1 in CVDs, which shed light on the understanding of the molecular mechanisms of CVDs and understanding the therapeutic potential of NEAT1.

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Funding

XJ is supported by National Science Foundation of China (31100834) and National Science Foundation of Shaanxi Province (2020JM-011).

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  1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, 710061, China

    Xiaoying Jiang

  2. Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, China

    Mingjuan Zhang

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Correspondence to Xiaoying Jiang.

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Jiang, X., Zhang, M. The roles of long noncoding RNA NEAT1 in cardiovascular diseases. Hypertens Res 47, 735–746 (2024). https://doi.org/10.1038/s41440-023-01551-0

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