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Structural changes in renal arterioles are closely associated with central hemodynamic parameters in patients with renal disease


Although central hemodynamics are known to be closely associated with microvascular damage, their association with lesions in the small renal arteries has not yet been fully clarified. We focused on arterioles in renal biopsy specimens and analyzed whether their structural changes were associated with noninvasive vascular function parameters, including central blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV). Forty-four nondiabetic patients (18–50 years of age) with preserved renal function underwent renal biopsy. Wall thickening of arterioles was analyzed based on the media/diameter ratio, and hyalinosis was analyzed by semiquantitative grading. Associations of these indexes (arteriolar wall remodeling grade index (RG index) and arteriolar hyalinosis index (Hyl index)) with clinical variables were analyzed. Multiple regression analyses demonstrated that the RG index was significantly associated with central systolic BP (β = 0.97, p = 0.009), serum cystatin C-based estimated glomerular filtration rate (β = −0.36, p = 0.04), and high-density lipoprotein cholesterol levels (β = −0.37, p = 0.02). The Hyl index was significantly associated with baPWV (β = 0.75, p = 0.01). Our results indicate that aortic stiffness and abnormal central hemodynamics are closely associated with renal microvascular damage in young to middle-aged, nondiabetic kidney disease patients with preserved renal function.

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Fig. 1
Fig. 2: Comparison of histopathological findings among the subgroups according to cSBP and baPWV (n = 44).


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The authors are indebted to Dr. Helena Akiko Popiel of the Department of International Medical Communications at Tokyo Medical University for her editorial review of the English manuscript. We also wish to thank Dr. Tatsuya Isomura of the Department of Clinical Consultation, Medical Research Institute, Tokyo Medical University, for providing statistical advice and the nephrologists of Tokyo Medical University for ensuring compliance with clinical study protocols.

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Correspondence to Yoshitaka Miyaoka.

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Miyaoka, Y., Okada, T., Tomiyama, H. et al. Structural changes in renal arterioles are closely associated with central hemodynamic parameters in patients with renal disease. Hypertens Res (2021).

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  • Arteriolar wall remodeling
  • Arteriolosclerosis
  • Central blood pressure
  • Pulse wave velocity
  • Renal biopsy


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