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Emerging role of NET inhibitors in cardiovascular diseases

Hypertension Research volume 43, pages 1459–1461 (2020)Cite this article

Extracellular vesicles, such as exosomes, microvesicles, and apoptotic bodies, have attracted much attention in recent years due to their plethora of associated functions. Extracellular vesicles have been implicated in several disease conditions, including cardiovascular diseases (CVDs) [1], autoimmune disorders, and cancer. In addition to these factors, a novel form of cell death known as NETosis has been defined and is also used synonymously to describe the process of neutrophil extracellular trap (NET) formation [2]. NETs are web-like structures formed by the decondensation of DNA and histone proteins with antimicrobial peptides embedded in them. These extracellular substances are rich in enzymes such as elastase, myeloperoxidase, gelatinase, proteinase 3, and other components such as cathepsin G, lactoferritin, pentraxin 3, cathelicidin LL37, and peptidoglycan-binding proteins. These proteins can target virulent proteins associated with microorganisms and are mostly implicated in infectious diseases. Recent evidence has found an association between NETs and the pathophysiology of several noncommunicable diseases caused by inflammatory reactions. The present commentary briefly discusses the role of NET inhibitors in ameliorating the effect of CVDs.

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  1. BRULAC-DRC, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, India

    Vijayashree Priyadharsini Jayaseelan & Arumugam Paramasivam

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  1. Vijayashree Priyadharsini Jayaseelan
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  2. Arumugam Paramasivam
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Correspondence to Vijayashree Priyadharsini Jayaseelan.

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Jayaseelan, V.P., Paramasivam, A. Emerging role of NET inhibitors in cardiovascular diseases. Hypertens Res 43, 1459–1461 (2020). https://doi.org/10.1038/s41440-020-0527-9

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