Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

A pilot proteomic study with a prospective cohort suspected to develop preeclampsia

Hypertension Research volume 43, pages 1319–1321 (2020)Cite this article

Preeclampsia (PE) is a common obstetric multisystem disorder that occurs in 2–5% of pregnancies worldwide [1]. Numerous efforts have been made to predict PE development in certain targeted pregnant populations of different gestational ages. However, due to the relatively low prevalence, screening the general population in early pregnancy did not offer an effective method for the prediction of PE [1, 2]. Recently, the serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and especially the ratio of sFlt-1 to PlGF were suggested to exclude PE in suspected women with elevated blood pressure or proteinuria. More specifically, even though the negative predictive value of the sFlt-1/PlGF ratio was adequate and as high as 99.3%, its positive predictive value was only 36.7%, suggesting its limited value in the prediction of the presence of PE in high-risk populations [3].

As part of the continual efforts in identifying the novel serum predictors, we employed the isobaric tags for relative and absolute quantitation (iTRAQ) technique to reveal the proteomic changes in the sera from a prospective cohort suspected to develop PE, followed by validation experiments by enzyme-linked immunosorbent assays (ELISAs) and western blotting. For the prospective cohort, the pregnant women with PE-related clinical and/or laboratory presentations had their blood drawn at their first visits and were followed up for PE development until delivery (see details in the Supplementary Methods).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15:275–89.

    Article  Google Scholar 

  2. De Kat AC, Hirst J, Woodward M, Kennedy S, Peters SA. Prediction models for preeclampsia: a systematic review. Pregnancy Hypertens. 2019;16:48–66.

    Article  Google Scholar 

  3. Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstrom M, et al. Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374:13–22.

    Article  CAS  Google Scholar 

  4. Anand S, Bench Alvarez TM, Johnson WE, Esplin MS, Merrell K, Porter TF, et al. Serum biomarkers predictive of pre-eclampsia. Biomark Med. 2015;9:563–75.

    Article  CAS  Google Scholar 

  5. Taitubayeva GK, Gribacheva IA, Bulekbayeva SA, Daribayev ZR, Petrova EV. Autonomic dysfunction syndrome in pregnant women. Acta Neurologica Belgica. 2020. https://doi.org/10.1007/s13760-020-01312-7. Online ahead of print.

  6. Konijnenberg A, Stokkers EW, van der Post JA, Schaap MC, Boer K, Bleker OP, et al. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol. 1997;176:461–9.

    Article  CAS  Google Scholar 

  7. Amann K, Haas CS, Zeiler GA, Benz K, Bader BL, Hartner A, et al. Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertension. Eur J Clin Investig. 2009;39:116–25.

    Article  CAS  Google Scholar 

  8. Martin-Lopez E, Blanchart A, De Carlos JA, Lopez-Mascaraque L. Dab1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages. PLoS ONE. 2011;6:e26673.

    Article  CAS  Google Scholar 

  9. Gao Z, Chen X, Zhu K, Zeng P, Ding G. Dab1 contributes to angiotensin II-induced apoptosis via p38 signaling pathway in podocytes. Biomed Res Int. 2017;2017:2484303.

    PubMed  PubMed Central  Google Scholar 

  10. Beary M, Hodgson R, Wildgust HJ. A critical review of major mortality risk factors for all-cause mortality in first-episode schizophrenia: clinical and research implications. J Psychopharmacol. 2012;26:52–61.

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81702057).

Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China

    Jingrui Liu, Lu Chen, Jing Wang, Sien Zhan, Ying Dong, Guodong Tang, Yifan Lu, Yanhong Zhai & Zheng Cao

  2. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China

    Xiaowei Liu, Shenglong Zhao & Yuanyuan Zheng

  3. Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Siqi Hu

Authors
  1. Jingrui Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaowei Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shenglong Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yuanyuan Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jing Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sien Zhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Siqi Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ying Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Guodong Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yifan Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Yanhong Zhai
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Zheng Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zheng Cao.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Research Ethics Committee of the Beijing Obstetrics and Gynecology Hospital.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, J., Liu, X., Zhao, S. et al. A pilot proteomic study with a prospective cohort suspected to develop preeclampsia. Hypertens Res 43, 1319–1321 (2020). https://doi.org/10.1038/s41440-020-0484-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41440-020-0484-3

Search

Advanced search

Quick links