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Antioxidative effect of an oral adsorbent, AST-120, and long-term outcomes in chronic kidney disease patients with cardiovascular disease

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Acknowledgements

To conduct this trial, an outsourcing agreement was signed between Dokkyo Medical University and Mitsubishi Tanabe, Co., Ltd., Tokyo, Japan. We appreciate the efforts of Ayumi Matsunuma, Clinical Research Coordinator, and Mikie Ogawa, Research Associate in the Department of Cardiovascular Medicine, Dokkyo Medical University, for data acquisition and technical support. We also thank Kiyosoh Yamagata, Kureha Special Laboratory Co., Ltd., for his assistance with the statistical analyses.

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Correspondence to Shigeru Toyoda.

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Conflict of interest

TI2 has received honorariums from Tanabe Mitsubishi, Astrazeneca, Daiichi Sankyo, and Boehringer Ingelheim. IT has received honorariums from Tanabe Mitsubishi, Astrazeneca, Bristol-Myers Squibb, Bayer, Takeda, Daiichi Sankyo, Otsuka, MSD, Shionogi, Kowa, Sumitomo Dainippon Pharma, and NIPRO LTD. TI2 and IT have received research grants from JSPS Grants-in-Aid for Scientific Research, Esai, Chugai, Astrazeneca, Bristol-Myers Squibb, Bayer, Takeda, Daiichi Sankyo, Otsuka, MSD, Boehringer Ingelheim, Teijin Pharma, Ono, Shionogi, Mitsubishi Tanabe, Kowa, Mochida, Sanwa Kagaku Kenkyusho, Sumitomo Dainippon Pharma, and NIPRO LTD. TI1 has received research grants from Astellas, Abbott Vascular, Boehringer Ingelheim, Bayer, Boston Scientific, Sanwa Kagaku Kenkyusho, Teijin Pharma, Takeda, Mitsubishi Tanabe, and Medtronic. The remaining authors declare no conflicts of interest.

Ethics

The study was conducted in accordance with the Declaration of Helsinki and all local regulatory requirements. Patients were required to give informed consent before randomization. The final protocol, its amendments, and informed consent documentation were reviewed and approved by the Dokkyo Medical University review boards. Opt-out consent was accepted from each patient for the current retrospective analysis.

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Toyoda, S., Hashimoto, R., Tezuka, T. et al. Antioxidative effect of an oral adsorbent, AST-120, and long-term outcomes in chronic kidney disease patients with cardiovascular disease. Hypertens Res 43, 1128–1131 (2020). https://doi.org/10.1038/s41440-020-0465-6

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