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Inflammatory and oxidative responses to disturbed blood flow in hypertensive men

Hypertension Research volume 42, pages 1832–1835 (2019)Cite this article

Atherosclerosis is a chronic inflammatory arterial disease that underlies many of the common causes of cardiovascular death/disability worldwide [1]. Atherosclerosis develops preferentially in irregular arterial regions that are exposed to disturbed blood flow (DBF), e.g., curvatures and bifurcations [2]. The close relationship between DBF and atherogenesis relies on endothelial dysfunction, which is associated with a proinflammatory phenotype with a higher level of reactive oxygen species production, elevated cell turnover, greater cell–cell permeability, and upregulated expression of adhesion molecules and chemokines [3]. These mechanisms are also common pathways in the pathophysiology of hypertension [4]. However, it is unclear whether similar DBF-induced inflammatory and oxidative responses occur in healthy and hypertensive subjects.

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Acknowledgements

This study was financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, the National Council of Scientific and Technological Development (CNPq) and the Foundation for Research Support of Rio de Janeiro (FAPERJ), Brazil.

Funding

National Council of Scientific and Technological Development (CNPq), Brazil; (Universal: 462265/2014-5; NGR); Foundation for Research Support of Rio de Janeiro (FAPERJ), Brazil (APQ 1: E-26/111.339/2014; NGR); Higher Education Personnel Improvement Coordination (CAPES), Brazil (Code 001; ASS, HNMR, VPG, GMSB).

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Authors and Affiliations

  1. Laboratory of Exercise Sciences (LACE), Department of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil

    Amanda S. Storch, Helena N. M. Rocha, Vinicius P. Garcia, Gabriel M. S. Batista, João Dario Mattos, Monique O. Campos, Antonio Claudio L. Nóbrega, Igor A. Fernandes & Natalia G. Rocha

  2. National Institute of Science and Technology (INCT)— Physical (In)activity and Exercise, National Council for Scientific and Technological Development (CNPq), Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil

    Antonio Claudio L. Nóbrega & Natalia G. Rocha

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  1. Amanda S. Storch
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  2. Helena N. M. Rocha
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Correspondence to Natalia G. Rocha.

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Storch, A.S., Rocha, H.N.M., Garcia, V.P. et al. Inflammatory and oxidative responses to disturbed blood flow in hypertensive men. Hypertens Res 42, 1832–1835 (2019). https://doi.org/10.1038/s41440-019-0296-5

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