This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Leong XF, Ng CY, Jaarin K. Animal models in cardiovascular research: hypertension and atherosclerosis. BioMed Res Int. 2015;2015:528757.
Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease. J Clin Invest 2016;126:821–8.
Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol 2009;10:53–62.
Rocha HNM, Garcia VP, Batista GMS, Silva GM, Mattos JD, Campos MO, et al. Disturbed blood flow induces endothelial apoptosis without mobilizing repair mechanisms in hypertension. Life Sci 2018;209:103–10.
Storch AS, Rocha HNM, Garcia VP, Batista G, Mattos JD, Campos MO, et al. Oscillatory shear stress induces hemostatic imbalance in healthy men. Thromb Res 2018;170:119–25.
James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507–20.
Garcia VP, Rocha HN, Silva GM, Amaral TA, Secher NH, Nobrega AC, et al. Exogenous l-arginine reduces matrix metalloproteinase-2 and -9 activities and oxidative stress in patients with hypertension. Life Sci. 157:125–30.
Takeda Y, Marumo M, Nara H, Feng ZG, Asao H, Wakabayashi I. Selective induction of anti-inflammatory monocyte-platelet aggregates in a model of pulsatile blood flow at low shear rates. Platelets 2016;27:583–92.
Gudbrandsdottir S, Hasselbalch HC, Nielsen CH. Activated platelets enhance IL-10 secretion and reduce TNF-alpha secretion by monocytes. J Immunol 2013;191:4059–67.
Passerini AG, Polacek DC, Shi C, Francesco NM, Manduchi E, Grant GR, et al. Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc Natl Acad Sci USA 2004;101:2482–7.
This study was financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, the National Council of Scientific and Technological Development (CNPq) and the Foundation for Research Support of Rio de Janeiro (FAPERJ), Brazil.
National Council of Scientific and Technological Development (CNPq), Brazil; (Universal: 462265/2014-5; NGR); Foundation for Research Support of Rio de Janeiro (FAPERJ), Brazil (APQ 1: E-26/111.339/2014; NGR); Higher Education Personnel Improvement Coordination (CAPES), Brazil (Code 001; ASS, HNMR, VPG, GMSB).
Conflict of interest
The authors declare that they have no conflict of interest.
Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Storch, A.S., Rocha, H.N.M., Garcia, V.P. et al. Inflammatory and oxidative responses to disturbed blood flow in hypertensive men. Hypertens Res 42, 1832–1835 (2019). https://doi.org/10.1038/s41440-019-0296-5