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Gender difference in the effects of cacao polyphenols on blood pressure and glucose/lipid metabolism in prediabetic subjects: a double-blinded, randomized, placebo-controlled crossover trial

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  1. 1.

    Buijsse B, Weikert C, Drogan D, Bergmann M, Boeing H. Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults. Eur Heart J. 2010;31:1616–23.

  2. 2.

    Galleano M, Oteiza PI, Fraga CG. Cocoa, chocolate, and cardiovascular disease. J Cardiovasc Pharmacol. 2009;54:483–90.

  3. 3.

    Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, et al. Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol. 2008;51:2141–9.

  4. 4.

    Blenck CL, Harvey PA, Reckelhoff JF, Leinwand LA. The importance of biological sex and estrogen in rodent models of cardiovascular health and disease. Circ Res. 2016;118:1294–312.

  5. 5.

    Kander MC, Cui Y, Liu Z. Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases. J Cell Mol Med. 2017;21:1024–32.

  6. 6.

    Natsume M, Osakabe N, Yamagishi M, Takizawa T, Nakamura T, Miyatake H, et al. Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC. Biosci Biotech Biochem. 2000;64:2581–7.

  7. 7.

    Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res. 2002;25:359–64.

  8. 8.

    du Plooy CS, Martha Cornelia Mels C, Huisman HW, Kruger R. The association of endothelin-1 with markers of oxidative stress in a biethnic South African cohort: the SABPA study. Hypertens Res. 2017;40:189–95.

  9. 9.

    Sankar P, Zachariah B, Vickneshwaran V, Jacob SE, Sridhar MG. Amelioration of oxidative stress and insulin resistance by soy isoflavones (from Glycine max) in ovariectomized Wistar rats fed with high fat diet: the molecular mechanisms. Exp Gerontol. 2015;63:67–75.

  10. 10.

    Emanuel AL, Meijer RI, Muskiet MH, van Raalte DH, Eringa EC, Serné EH. Role of insulin-stimulated adipose tissue perfusion in the development of whole-body insulin resistance. Arterioscler Thromb Vasc Biol. 2017;37:411–8.

  11. 11.

    Morimoto K, Uji M, Ueyama T, Kimura H, Kohno T, Takamata A, et al. Estrogen replacement suppresses pressor response and oxidative stress induced by cage-switch stress in ovariectomized rats. Ann NY Acad Sci. 2008;1148:213–8.

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Conflict of interest

KS, HT, and AY received a research grant for this study from Meiji Co., Ltd. The other authors declare that they have no conflict of interest.

Correspondence to Hirofumi Tomiyama.

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